整合子与细菌耐药相关性研究进展  

Progress on the correlation between integrons and bacterial drug resistance

作　　者：李情操[1] 魏取好[2] 卢雯君[1] 赵玉杰[1] 

机构地区：[1]宁波市医疗中心李惠利医院检验科,浙江宁波315040 [2]浙江省人民医院检验科,浙江杭州310014

出　　处：《检验医学》2016年第4期324-328,共5页Laboratory Medicine

基　　金：浙江省自然基金资助项目(Y2110743)

摘　　要：整合子是近年来被发现的一种新的遗传结构元件,能够识别外界的耐药基因,可以通过位点特异性重组的方式捕获耐药基因并使其表达;也可以位于质粒或转座子上,作为质粒或转座子的一个组成部分,在转移的过程中使耐药基因在细菌中发生播散。整合子因为与细菌耐药性的产生和传播关系密切而备受各方的关注。Integron is a mobile gene element being found recently. It could recognize drug resistance gene from outside. It can also recombine exogenous gene and express by site-specific recombination. In addition,integron is located at transposon or plasmid,and by being a part of it transmitting drug resistance gene. Researches on integron are attracting many interests for its importance in the generation of drug resistance and transmission.

关 键 词：整合子 耐药基因 传播 

分 类 号：R446.5[医药卫生—诊断学]