川崎病的精准治疗  

Precise treatment for Kawasaki disease

作　　者：孙乐[1] 李雪梅[1] 于宪一[1] 

机构地区：[1]中国医科大学附属盛京医院小儿心血管内科,沈阳110004

出　　处：《中国中西医结合儿科学》2016年第2期132-135,共4页Chinese Pediatrics of Integrated Traditional and Western Medicine

摘　　要：川崎病是一种急性全身性血管炎症,主要见于婴儿及5岁以下儿童。冠状动脉损伤是其最严重并发症。在未治疗患儿中冠状动脉损伤发生率高达25%。在急性期应用大剂量丙种球蛋白能尽快缓解临床症状并大大降低冠状动脉损伤的风险。对于丙种球蛋白治疗无反应性的川崎病,糖皮质激素、英夫利昔单克隆抗体等一些辅助治疗方法近年来在临床上也有所应用。本文就川崎病急性期过后的治疗与管理情况也分别进行了概述。Kawasaki disease（KD）is an acute systemic vasculitis mainly affecting infants and children under 5years old.Coronary artery lesions（CALs）are the most serious complication.KD is liable to be complicated by coronary artery lesion（CAL）in approximately 25% of untreated KD children.In the acute phase,high dose of intravenous immunoglobulin（IVIG）can relieve symptoms quickly and significantly reduce the risk of CAL.Some adjunctive therapies,including glucocorticoids and infliximab,have been used in treatment of IVIG resistant KD over the past few years.This article also introduces the treatment and management of KD after the acute phase.

关 键 词：川崎病 冠状动脉损伤 丙种球蛋白 治疗 后期管理 儿童 

分 类 号：R725.4[医药卫生—儿科]