双歧杆菌三联活菌散对特应性体质毛细支气管炎患儿免疫球蛋白E和白细胞介素17水平的影响  

Effects of live combined bifidobacterium, lactobacillus and enterococcus powder on IgE and interleukin - 17 levels in atopic children with bronchiolitis

作　　者：薛国昌[1] 任明星[1] 沈琳娜[1] 夏欢[1] 宋月娟[1] 夏雪霞[1] 

机构地区：[1]苏州大学附属无锡市第九人民医院儿科,214062

出　　处：《中华实用儿科临床杂志》2016年第10期776-778,共3页Chinese Journal of Applied Clinical Pediatrics

摘　　要：目的观察双歧杆菌三联活菌散对特应性体质毛细支气管炎患儿免疫球蛋白E（IgE）和白细胞介素-17（IL-17）的影响。方法将60例毛细支气管炎患儿按随机数字表法分为治疗组（30例）和对照组（30例），并设健康对照组25例；对照组按毛细支气管炎常规治疗，治疗组除常规治疗外，加用双歧杆菌三联活菌散治疗2个月。于急性期、恢复期及口服双歧杆菌三联活菌散2个月后检测血清IgE和IL-17水平。结果1．治疗组患儿急性期IgE、IL-17水平[（132．36±9．50）μg/L、（77．76±7．95）μg/L]均高于健康对照组[（52．80±4．92）μg/L、（46．92±4．79）μg/L]，差异均有统计学意义（P均〈0．001）；对照组患儿急性期IgE、IL-17水平[（128．83±8．06）μg/L、（76．61±6．18）μg/L]均高于健康对照组[（52．80±4．92）μg/L、（46．92±4．79）μg/L]，差异均有统计学意义（P均〈0．001）。2．口服双歧杆菌三联活菌散2个月后，治疗组IgE水平[（56．67±9．20）μg/L]低于对照组[（70．50±11．38）μg/L]，差异有统计学意义（P〈0．001）。治疗组IL-17水平[（49．63±6．35）μg/L]低于对照组[（54．77±6．33）μg/L]，差异有统计学意义（P=0．003）。结论口服双歧杆菌三联活菌散能下调特应性体质毛细支气管炎患儿IgE和IL-17的水平。Objective To observe the effects of live combined bifidobacterium,lactobacillus and enterococcus powder on immunoglobulin E （IgE） and interleukin -17 （IL- 17 ） in atopic children with bronchiolitis. Methods Sixty cases of atopic children with bronchiolitis were randomly divided into the therapy group （30 cases） and the con- trol group （30 cases）. Twenty -five healthy children were enrolled as the healthy control group. Both the therapy group and the control group were given traditional therapy. The therapy group received live combined bifidobacterium, lactoba- cillus and enterococcus powder for 2 months. The change of IgE and IL - 17 levels were observed during the acute stage,remission stage and after receiving live combined bifidobacterium,lactobacillus and enterococcus powder for 2 months. Results （1） The levels of IgE andIL-17 of therapy group[（132.36±9.50） μg/L and （77.76±7.95）μg/L] during acute stage were markedly higher than those in the healthy control group [ （52.80 ±4.92） μg/L and （46.92 ± 4.79） μg/L] （ all P 〈 0. 001 ）. The levels of IgE and IL - 17 of control group [ （ 128.83 ± 8.06） μg/L and （76.61 ± 6.18 ） μg/L] during remission stage were markedly higher than those in the healthy control group [ （52.80 ± 4.92 ） μg/L and （46.92 ± 4.79 ） μg/L ] （ all P 〈 0. 001 ）. （ 2 ） The levels of IgE of therapy group （ 56.67±9.20 ） μg/L after receiving live combined bifidobacterium, lactobacillus and enterococcus powder for 2 months were markedly lower than those in the control group （70.50 ±11.38） μg/L （P 〈0. 001 ）. The levels of IL - 17 of therapy group [ （49.63 ± 6.35 ）μg/L ] at the time after receiving live combined bifidobacterium, lactobacillus and enterococcus pow- der for 2 months were markedly lower than these in the control group （ 54.77± 6.33 ） μg/L （ P = 0.003 ）. Conclusion Receiving live combined bifidobacterium, lactobaeillus and enterococcus powder for two months can decrease the I

关 键 词：毛细支气管炎 双歧杆菌三联活菌散 免疫球蛋白E 白细胞介素17 

分 类 号：R725.6[医药卫生—儿科]