阿托伐他汀的抗炎作用及其机制的研究进展  

Advance in the Anti-inflammatory Effect and Mechanism of Atorvastatin

作　　者：徐健强[1] 赵国军[2] 王燕[3] 喻思扬 曾高峰[1] 

机构地区：[1]南华大学附属第二医院心血管内科,湖南省衡阳市421001 [2]桂林医学院组织胚胎学教研室,广西桂林市541004 [3]南华大学附属第二医院麻醉科,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2016年第4期419-423,共5页Chinese Journal of Arteriosclerosis

基　　金：湖南省自然科学基金资助项目(14JJ5016)

摘　　要：阿托伐他汀具有强效降脂功能,目前已被广泛用于高脂血症和心血管疾病的治疗。此外,阿托伐他汀还能明显抑制白细胞介素1β(IL-1β)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)等促炎因子的合成,具有显著抗炎效应。但是,阿托伐他汀抗炎效应的具体机制还未完全阐明。本文综述了Toll样受体(TLR)、炎性体、microRNA(miRNA)、小G蛋白和过氧化体增殖物激活型受体(PPAR)在阿托伐他汀抗炎效应中的作用,为深入认识阿托伐他汀的抗炎机制提供了依据。As we know,atorvastatin has been widely used to treat hyperlipidaemia and cardiovascular diseases.Atorvastatin also has anti-inflammatory effect on inhibiting the expression of pro-inflammatory cytokines,such as interleukin-1β,interleukin-6 and tumor necrosis factor-α,etc.However,the underlying mechanisms of anti-inflammatory effect of atorvastatin are still largely unknown.In this review,we summarize the progress of Toll-like receptors,inflammasome,microRNAs,small GTPase and peroxisome proliferator-activated receptors on the anti-inflammatory effect of atorvastatin,in order to provide new evidence for further understanding of the anti-inflammatory mechanisms of atorvastatin.

关 键 词：阿托伐他汀 TOLL样受体 炎性体 小G蛋白 microRNA 过氧化体增殖物激活型受体 

分 类 号：R5[医药卫生—内科学]