神经导向因子Netrin-1调节单核巨噬细胞迁移与动脉粥样斑块关系的研究进展  

Research Progress on the Relationship Between Neural Guidance Factor Netrin-1Regulating Macrophage Migration and Atherosclerotic Plaque

作　　者：易玉红 张璐璐[1] 彭道泉[1] 

机构地区：[1]中南大学湘雅二医院心内科,湖南省长沙市410011

出　　处：《中国动脉硬化杂志》2016年第4期429-432,共4页Chinese Journal of Arteriosclerosis

摘　　要：动脉粥样硬化是动脉壁的一种慢性炎症性疾病,单核巨噬细胞在其发生发展中起着关键作用。动脉粥样斑块中单核巨噬细胞迁移能力受损,滞留于斑块内,增加了斑块不稳定性,加速动脉粥样硬化病变的进展。目前研究表明动脉粥样斑块中巨噬细胞分泌的神经导向因子Netrin-1通过与巨噬细胞表面相应受体结合,可以抑制巨噬细胞迁出斑块,促进动脉粥样硬化的进展。但在动脉粥样硬化形成初期,血管内皮细胞表达的Netrin-1却被发现对动脉粥样硬化起到保护作用。Atherosclerosis is recognized as a chronic inflammatory disease of the artery wall,in which monocytes/macrophages plays a key role in its development.The migration ability of monocytes /macrophages is damaged in atherosclerotic plaque,and retained in plaque.This increases plaque instability and accelerates the progression of atherosclerotic lesions.Recent studies show that neural guidance factor netrin-1,secreted by macrophages in atherosclerotic plaque,can inhibit macrophage migration out of plaque and promote the progress of atherosclerosis,through binding to receptors on the surface of macrophages.However,in the early stage of atherosclerosis,netrin-1 expressed in vascular endothelial cells is found to play a protective role in atherosclerosis.

关 键 词：神经导向因子 NETRIN-1 单核巨噬细胞迁移 动脉粥样硬化 

分 类 号：R541.4[医药卫生—心血管疾病]