川麦冬药材中二氧化硫来源及残留积累动态分析  

Sources and Residue Accumulation Dynamic Analysis of Sulfur Dioxide in Ophiopogonis Radix

作　　者：吴发明[1] 张德林[1] 陈辉[1] 包小红 李敏[1] 周娟 

机构地区：[1]成都中医药大学,成都611137 [2]四川省食品药品检验检测院,成都611130

出　　处：《中国实验方剂学杂志》2016年第9期12-15,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"重大新药创制"科技重大专项(2014ZX09304307-002);国家科技部科技惠民项目(2013GS510102);四川省中医管理局科研项目(2014F038);四川省科技厅科技支撑项目(2015SZ0033)

摘　　要：目的:分析川麦冬药材中SO_2来源及残留量积累动态变化,为解决其SO_2残留超标问题提供理论依据。方法:收集主产区不同方法加工的川麦冬药材28份,测定SO_2残留量,根据测定结果对煤炭火烘烤和熏硫2种加工方法在加工过程中川麦冬药材SO_2残留积累动态进行考察。结果:产地收集的28份样品中SO_2残留量超标率35.71%,SO_2来源为煤炭火烘烤和硫磺熏蒸。SO_2残留量和烘烤时间成正比,超标临界时间在8~10 h;SO_2残留量和硫磺熏蒸时间、药材水分含量均呈正比关系,鲜麦冬熏硫1 h后SO_2残留量可高到1 017.69 mg·kg^(-1)。结论:从麦冬药材质量和安全用药考虑,在麦冬产地加工过程中应当禁止熏硫并严格控制煤炭火烘烤时间。Objective： To analyze sources and residue accumulation dynamic change of SO2 in Ophiopogonis Radix for providing a theoretical basis to solute problem that SO2 residue in Ophiopogonis Radix exceeded the standard. Method： Twenty-eight medicinal materials of Ophiopogonis Radix were collected,which were processed with different methods in main producing area of Sichuan. Residue of SO2 in samples were measured. Based on measurement results and after processed by coal fire baking and smouldering sulphur,residue accumulation dynamic change of SO2 in Ophiopogonis Radix were investigated. Result： Residue of SO2 in 28samples exceeded the standard with rate of 35. 71%. Sources of SO2 residue were coal fire baking and smouldering sulphur. SO2 residue was in direct proportional to baking time. Marginal time of SO2 residue out of the limit was8 -1 0 h. SO2 residue was also in direct proportional to smoked sulfur time and material moisture content. SO2 residue reached up to 1 017. 69 mg·kg-1 when fresh Ophiopogonis Radix was processed with smouldering sulphur for only 1 h. Conclusion： Consider of quality and medicine safety of Ophiopogonis Radix,it should be forbidden with smouldering sulphur and control baking time strictly in processing of Ophiopogonis Radix.

关 键 词：麦冬 干燥方式 二氧化硫 含水量 熏硫时间 

分 类 号：R932[医药卫生—生药学] R282.4[医药卫生—药学]