天麻钩藤饮对风阳上扰型急性脑梗死患者血脂,CAT水平的影响  

Effect of Tianma Gouteng Decoction on Levels of Blood Lipid and CAT for Patients with Wind-Yang Nuisance Type Acute Cerebral Infarction

作　　者：王艳旭[1] 李世举[2] 王芳[1] 黄健[1] 林卿[1] 高千仞[1] 

机构地区：[1]福建中医药大学附属人民医院,福州350004 [2]福建中医药大学附属第二人民医院,福州350003

出　　处：《中国实验方剂学杂志》2016年第9期139-142,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：福建省卫生厅青年科研课题(2011-2-34)

摘　　要：目的:观察天麻钩藤饮对风阳上扰型急性脑梗死患者血脂、血清过氧化氢酶(CAT)水平的影响。方法:选择风阳上扰型急性脑梗死患者68例,随机分为治疗组和对照组各34例,对照组给予脑梗死常规治疗(口服拜阿司匹林100 mg,qd和立普妥20 mg,qn),治疗组在脑梗死常规治疗基础上加服天麻钩藤饮汤剂,以7 d为1个疗程,共治疗2个疗程。观察治疗前后血脂水平,CAT水平变化,测定治疗前后神经功能缺损评分及中医证候积分的变化。结果:与对照组比较,治疗组总胆固醇(TC),甘油三酯(TG),低密度脂蛋白胆固醇(LDL-C)和载脂蛋白-B(Apo-B)水平均降低,分别为(4.08±0.67),(1.20±0.65),(1.98±0.24)mmol·L^(-1),(1.03±0.41)g·L^(-1),而CAT水平明显升高(20.07±5.83)U·L^(-1),两组治疗后比较有统计学意义(P<0.05,P<0.01);治疗组神经功能缺损评分和中医证候积分均降低,分别为(3.65±2.15)分,(9.27±7.11)分,两组治疗后比较有统计学意义(P<0.05)。治疗组总有效率为88.2%,对照组总有效率为79.4%,治疗组临床疗效更为显著(P<0.05)。结论:天麻钩藤饮可以有效的降低风阳上扰型急性脑梗死的血脂水平、升高CAT水平,从而提高患者抗氧化能力。Objective： To observe the effect of Tianma Gouteng decoction on the levels of blood lipid and catalase（ CAT） in patients with wind-Yang nuisance type acute cerebral infarction. Method： Sixty-eight patients with wind-Yang nuisance type acute cerebral infarction were randomly divided into treatment group（ 34cases） and control group（ 34 cases）. The patients in control group received conventional cerebral infarction treatment（ bayaspirin 100 mg qd and lipitor 20 mg qn）,and the patients in the treatment group also received Tianma Goutengyin decoction on the basis of conventional treatment in control group,for a total of 2 treatment courses,with 7 days as one course of treatment. The changes of blood lipid,CAT,neurological function defect scores,and traditional Chinese medicine（ TCM） symptom scores were detected before and after treatment.Result： Compared with those of the control group,the levels of total cholesterol（ TC）,triglyceride（ TG）,lowdensity lipoprotein cholesterol（ LDL-C） and apolipoprotein-B（ Apo-B） in the treatment group were reduced（ 4. 08 ± 0. 67）,（ 1. 20 ± 0. 65）,（ 1. 98 ± 0. 24） mmol·L-1,（ 1. 03 ± 0. 41） g·L-1,while the level of CAT was increased（ 20. 07 ± 5. 83） U·L-1,there was statistical significance between two groups after treatment（ P〈0. 05,P〈0. 01）. The neural function defect score and TCM score were reduced in treatment group（ 3. 65 ±2. 15）,（ 9. 27 ± 7. 11）,there was statistical significance between two groups after treatment（ P〈0. 05）. The total effective rate was 88. 2% in the treatment group and 79. 4% in the control group. The treatment group was better than the control group in clinical efficacy（ P〈0. 05）. Conclusion： Tianma Gouteng decoction can effectively reduce the levels of blood lipid and increase the CAT level,so that improve the antioxidant capacity in patients with wind-Yang nuisance type acute cerebral infarction.

关 键 词：天麻钩藤饮 脑梗死 风阳上扰 血脂 血清过氧化氢酶 

分 类 号：R287.6[医药卫生—中药学]