诱导多能干细胞在血液系统疾病中的研究进展  

Research Progress on Induced Pluripotent Stem Cells in Hematopoietic Diseases

作　　者：范荻[1] 孙筱放[1] 

机构地区：[1]广州医科大学附属第三医院广东省产科重大疾病重点实验室广东普通高校生殖与遗传重点实验室,广州510150

出　　处：《生物技术通报》2016年第4期34-38,共5页Biotechnology Bulletin

基　　金：国家自然科学基金项目(U1132005);国家自然科学基金项目(31171229)

摘　　要：造血干细胞移植(hemopoietic stem cell transplantation,HSCT)用于血液系统疾病的治疗已取得迅猛发展。但由于供体有限及配型效率不高等问题,严重阻碍了其在临床上的广泛应用。因此,人们迫切地寻求更为安全、经济和有效的造血干细胞的资源。诱导多能干细胞(induced pluripotent stem cells,i PS)在体外可被诱导分化为多种细胞,其中对体外诱导分化为造血干细胞的研究尤为深入。该文就i PS细胞在体外定向分化为造血干细胞及移植研究的最新进展作一综述。Hematopoietic stem cell transplantation for the treatment of blood system diseases has been had great progress. However,due to the issues of limited donor and matching efficiency is not high,which seriously hindered its wide application in clinic. It is imperative to seek more secure,economical and effective resources of hematopoietic stem cell. Induced pluripotent stem cells can be differentiated into a variety of cells in vitro,especially deeper research on induced differentiation into hematopoietic stem cells in vitro. In this paper,i PS cells directed differentiation to hematopoietic stem cells in vitro and research progress on transplant are reviewed.

关 键 词：造血干细胞移植 诱导多能干细胞 造血分化 

分 类 号：R55[医药卫生—血液循环系统疾病]