红外热成像法研究半胱氨酸修饰金纳米棒的光热抗肿瘤效果  

NIR Sensitive Hyperthermia Antitumor of Cysteine Modified Gold Nanorods via Infrared Thermal Imaging Method

作　　者：常贯儒[1,2] 鲁信勇 胡逢恺[1] 陈龙[1] 潘成兵 

机构地区：[1]黄山学院化学化工学院,安徽黄山245041 [2]安徽大学化学化工学院,安徽合肥230601

出　　处：《精细化工》2016年第5期491-496,共6页Fine Chemicals

基　　金：安徽省教育厅自然科学研究重点项目(KJ2016A679);安徽省高校优秀人才支持计划重点项目(gxyq ZD2016302);省级大学科研创新训练项目(201510375048;AH201310375053);黄山学院科研项目(2006xkjq007);安徽大学研究生学术创新研究项目(yqh100053)~~

摘　　要：通过配体交换法制备出两性离子半胱氨酸修饰的金纳米棒(Cys-Au NRs)以用于临床光热疗法。并在200 m W/cm2的近红外激光(808 nm)辐照下,对Cys-Au NRs进行了光热效果测试、红外热成像分析、细胞活性和荧光成像实验。当Cys-Au NRs的质量浓度为57 mg/L,Hela细胞的存活率仍高达90.1%,而光照10 min后,细胞存活率则锐减到60.1%。研究结果表明,Cys-Au NRs具有良好的生物相容性和较低的细胞毒性,且在近红外照射下,能够显著地杀死肿瘤细胞。Cys-Au NRs were prepared via ligands exchange method using zwitterionic cysteine to modify Au NRs for the clinical photothermal therapy. And the photothermal effect,the infrared thermal imaging,hyperthermia effect on tumor cells and fluorescence imaging experiment of Cys-Au NRs were investigated under irradiation by 808 nm NIR laser at a power density of 200 m W / cm^2. The survival rate of He La cells incubated with Cys-Au NRs at the mass concentration of 57 mg / L,still remains90. 1%. However,under NIR irradiation for 10 min,the survival rate of Hela cells sharply decreases to60. 1%. The results suggested that Cys-Au NRs have good biocompatibility and low cytotoxicity,can also kill tumor cells effectively under the laser radiation.

关 键 词：金纳米棒 半胱氨酸 光热治疗 红外热成像 荧光成像 功能材料 

分 类 号：TB383.1[一般工业技术—材料科学与工程]