Stathmin-1和p53蛋白与宫颈上皮内瘤变复发关系研究  

Study on the relationship of STMN-1 and p53 protein with the recurrence of cervical intraepithelial neoplasia

作　　者：孔守芳[1] 戴淑真[2] 姚勤[2] 吕腾[2] 孙选[1] 

机构地区：[1]青岛大学医学院青岛大学医学院附属青岛市海慈医疗集团妇科,山东青岛266033 [2]青岛大学附属医院妇科,山东青岛266033

出　　处：《中国实用妇科与产科杂志》2016年第5期457-459,共3页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：山东省青岛市科技局科技支撑计划(13-1-4-118-jch)

摘　　要：目的探讨Stathmin-1(STMN-1)和p53蛋白在预测高级别宫颈上皮内瘤变锥切术后复发的意义。方法收集2010-01-01—2013-01-30青岛大学附属医院收治的因高级别宫颈上皮内瘤变行宫颈锥切,术后复发病例30例为复发组,随机抽取同期因该疾病行宫颈锥切术随访2年无复发病例30例作对照组,调取两组患者初治时宫颈锥切组织蜡块,利用免疫荧光及免疫组化法对两组组织中STMN-1和p53蛋白表达进行检测。结果复发组p53蛋白阳性表达(70.0%)明显高于对照组(36.7%),STMN-1阳性表达(83.3%)明显高于对照组(33.3%),差异有统计学意义(P<0.05);复发组STMN-1与p53蛋白阳性率(70.0%)均明显高于对照组(26.7%),差异有统计学意义(P<0.05)。结论 STMN-1与p53蛋白过表达与宫颈上皮内瘤变术后复发相关,两者联合检测可作为对宫颈上皮内瘤变术后预后判断的生物指标。Objective To evaluate the relationship between Stathmin-1 and p53 protein expression and recurrent cervical intraepithelial neoplasia.Methods Totally 60 patients were selected who were confirmed CIN2 ~ 3 and treated with cervical conization from January 1st 2010 to January 30th 2013 in the Hospital Affliated to Medical College of Qingdao; 30 of those patients had recurrence and the other 30 didn＇t. Detect STMN- 1 and p53 protein by immunofluorescence and immunohistochemistry. Results The expression of STMN- 1 in recurrence patients was higher than in the others（P〈0.05）. The expression of p53 protein was higher, too（P〈0.05）. The recurrence patients had higher expression of both STMN-1 and p53 protein （P〈0.05）.Conclusion Overexpression of STMN-1 and p53 protein is related to recurrence of CIN, and the detection of both can be a biomarker in deciding the prognosis of CIN surgery.

关 键 词：宫颈上皮内瘤变 Stathmin-1 P53蛋白 宫颈锥切 复发 

分 类 号：R711.74[医药卫生—妇产科学]