血管生成素相关生长因子在腹主动脉瘤血浆中的变化及其意义  

Change of Serum Angiopoietin-related Growth Factor in Patients with Abdominal Aortic Aneurysm and Its Clinical Significance

作　　者：聂皓[1] 梁越[1] 任华亮[1] 王曰伟[2] 田翠[3] 李汇华[3] 郑月宏[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院血管外科,北京100730 [2]青岛大学附属医院血管外科,山东青岛266000 [3]首都医科大学生理学与病理生理学系,北京100069

出　　处：《中国医学科学院学报》2016年第2期150-154,共5页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(81270390)~~

摘　　要：目的探讨腹主动脉瘤患者血浆中血管生成素相关生长因子(AGF)水平的变化及其意义。方法分析50例腹主动脉瘤患者及56例健康体检者(对照组)血浆AGF水平。常规检测血生化指标及超敏C反应蛋白,采用酶联免疫分析方法测定血浆AGF、脂联素水平。结果腹主动脉瘤患者血浆AGF水平较对照组显著升高[(87.91±96.87)μg/L比(56.89±41.32)μg/L,P=0.040];脂联素水平二者比较差异无统计学意义。直径在3和5 cm之间的腹主动脉瘤和直径超过5 cm的腹主动脉瘤血浆AGF水平分别为(75.27±46.05)μg/L和(96.08±68.61)μg/L。结论腹主动脉瘤患者的血浆AGF水平升高,且升高的程度可以反映腹主动脉瘤的大小,可以作为潜在的腹主动脉瘤血清学生物标志物。Objective To investigate the changes and value of plasma angiopoietin-related growth factor（ AGF） in patients with abdominal aortic aneurysm（ AAA）. Methods Serum AGF level was analyzed in 50 AAA patients and in 56 healthy subjects. AGF and adiponectin were quantified by enzyme-linked immunosorbent assay. Routine testing of blood biochemistry and high-sensitivity C-reactive protein were performed. Results The plasma AGF level was significantly higher in AAA patients than in the controls [（ 87. 91 ± 96. 87） μg / L vs.（ 56. 89 ± 41. 32） μg/L,P = 0. 040],while serum adiponectin level showed no significant difference between these two groups. The plasma AGF level in patients with an AAA 〉5 cm and those with AAA between 3 cm and5 cm were（ 96. 08 ± 68. 61） μg / L and（ 75. 27 ± 46. 05） μg / L. Conclusions Plasma AGF is highly expressed in AAA patients. Higher serum AGF level is associates with larger AAA. Thus,AGF may be a potential serum

关 键 词：腹主动脉瘤 血管生成素相关生长因子 直径 诊断 破裂 临床意义 

分 类 号：R654.4[医药卫生—外科学]