中老年回汉族人群胰岛素抵抗及β细胞功能与脂代谢的关系  被引量:4

Association of Insulin Resistance and β Cell Function with Lipid Metabolism in Middle-aged and Elderly Hui and Han Populations

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作  者:李淑亚[1] 姜敏[2] 姚天宇[1] 程羽萱 范雅洁[1] 刘旭颖[1] 张金玲[1] 刘兰[3] 王志忠[3] 马玉英[4] 扈学琴[4] 王盼盼[4] 于晶晶[2] 马荣[2] 黄琦[2] 

机构地区:[1]宁夏医科大学研究生院,银川750004 [2]宁夏医科大学总医院暨生物芯片北京国家工程研究中心宁夏分中心,银川750004 [3]宁夏医科大学公共卫生学院流行病与卫生统计学系,银川750004 [4]宁夏医科大学总医院体检中心,银川750004

出  处:《中国医学科学院学报》2016年第2期192-197,共6页Acta Academiae Medicinae Sinicae

基  金:国家自然科学基金(81160049)~~

摘  要:目的对宁夏城市社区回汉族中老年人群的胰岛素抵抗及β细胞功能与体质量指数及血脂等影响因素进行关联性对比研究。方法选取宁夏城市地区40岁以上的社区调查者共1 000例,回汉比例1∶2。测量身高、体质量、腰围、臀围;三酰甘油(TG)、总胆固醇(TC)、血尿酸(BUA)、血糖、胰岛素,计算体质量指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(IR)、胰岛素敏感指数(IAI)、β细胞功能指数(HBCI)。结果回族的BMI、WHR、IAI、HBCI和糖尿病的患病比例均显著高于汉族(P<0.01),但是BUA、血糖、TC、IR均低于回族(P<0.01)。回族中TG、BMI、WHR、BUA与IR呈正相关(r分别为0.234、0.193、0.143、0.129,P<0.01),与IAI呈负相关(r分别为-0.234、-0.193、-0.143、-0.129,P<0.01),TC与HBCI呈负相关(r为-0.169,P<0.01);汉族中TC、TG、BMI、WHR、BUA均与IR呈正相关(r分别为0.140、0.257、0.288、0.163、0.104,P<0.01),与IAI呈负相关(r分别为-0.140、-0.257、-0.288、-0.163、-0.104,P<0.01),BMI与HBCI呈负相关(r为-0.111,P<0.01)。校正性别、民族、年龄因素后,TC、TG、BMI、WHR、BUA均与IR呈正相关(r分别为0.109、0.256、0.253、0.139、0.142,P<0.01),与IAI呈负相关(r分别为-0.109、-0.256、-0.253、-0.139、-0.142,P<0.01),TC、BMI与HBCI呈负相关(r=-0.113,r=-0.086,P<0.01)。多元回归分析显示TG、BMI与IR、IAI独立相关(r分别为0.218、0.182、-0.218、-0.182),TC、BMI与HBCI独立相关(r分别为-0.113、-0.086)。结论宁夏地区中老年人TC、TG、BMI、WHR、BUA和IR、IAI、HBCI的分布特征及其之间的关系存在着回汉族差异。校正性别、民族、年龄因素后,BMI、WHR、TC、TG、BUA与IR、IAI显著相关,BMI、TC与HBCI显著相关,TC、BMI可能对β细胞的分泌功能影响较大,而TG、BMI则主要与胰岛素抵抗及胰岛素敏感性相关。Objective To explore the association of insulin resistance and β cell function with lipid metabolism in middle-aged and elderly Hui and Han populations. Methods A total of 1 000 subjects age over40 years were recruited from five urban communities in Yinchuan and Wuzhong cities of Ningxia. The composition ratio between Hui and Han nationality was 1∶2. A questionnaire-based survey was performed. Physical examinations were carried out to measure the height, body mass, waistline, and hipline. The levels of triglyceride( TG),total cholesterol( TC),blood uric acid( BUA),fasting blood glucose and insulin were measured. The boby mass index( BMI),waist-hip ratio( WHR),and secretion related index including insulin resistance index( IR),insulin sensitivity index( IAI),and beta cell function index( HBCI) were calculated. Results The BMI,WHR,IAI,HBCI,and the prevalence rate of diabetes in Hui nationality were significantly higher than those in Han nationality( P〈 0. 01). The levels of BUA,fasting blood glucose,TC,and IR in Han nationality were significantly lower than those in Hui nationality( P〈 0. 01). In Hui populations,TG,BMI,WHR,and BUA were positively correlated with IR( r = 0. 234,r = 0. 193,r = 0. 143,and r = 0. 129,respectively; P 〈0. 01) and were negatively correlated with IAI( r =- 0. 234,r =- 0. 193,r =- 0. 143,r =- 0. 129,respectively; P〈 0. 01),whereas TC was negatively correlated with HBCI( r =- 0. 169,P 〈0. 01). In Han populations,TC,TG,BMI,WHR,and BUA were positively correlated with IR( r = 0. 140,r = 0. 257,r =0. 288,r = 0. 163,r = 0. 104,P 〈0. 01) and negatively correlated with IAI( r =- 0. 140,r =- 0. 257,r =- 0. 288,r =- 0. 163,and r =- 0. 104,P 〈0. 01),whereas BMI was negatively correlated with HBCI( r =- 0. 111,P〈 0. 01). After the influential factors such as gender,nationality,and age were adjusted,the TC,TG,BMI,WHR,BUA levels were positively correlated with IR( r = 0. 109,r = 0. 256,r = 0. 253,r =0. 139,and r = 0. 142

关 键 词:胰岛素抵抗指数 β细胞功能指数 体质量指数 腰臀比 胆固醇 三酰甘油 

分 类 号:R446.112[医药卫生—诊断学] R587.1[医药卫生—临床医学]

 

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