1872例冠心病增龄性临床研究  

Clinical research on aging in 1872 patients with coronary heart disease

作　　者：宋宏宾[1] 张伟民[1] 陈大楸[1] 向良浩[1] 

机构地区：[1]解放军第92医院心内科,福建南平353000

出　　处：《实用临床医药杂志》2016年第9期109-113,共5页Journal of Clinical Medicine in Practice

摘　　要：目的探讨冠心病（CHD）流行病学特征及相关危险因素,评价CHD与增龄的相关性。方法选取行Judkins法冠状动脉造影的患者1 872例,按年龄分为6组。比较1组（80岁,110例）的冠状动脉病变支数、病变血管分布、基础临床指标、Gensini积分。采用Logistic回归方法分析冠心病与年龄及危险因素的相关关系。结果 1组至6组的患病率分别为43.8%、50.5%、64.8%、74.5%、79.7%、80.0%。与〈40岁的人群相比,老年人年龄每增加10岁,冠心病的发病危险分别增加15%、48%、70%、82%、83%。男性冠心病患病率为74.7%,显著高于女性的60.4%（P〈0.01）。三支病变、患病率、Gensini积分随年龄的增加而上升。Logistic回归分析显示,冠心病的独立危险因素有年龄、性别、吸烟、饮酒、高血压、TC、HDL、UA。HDL是保护性因素。结论冠心病的发病风险随增龄而逐渐上升。男性、吸烟、高血压、TC为冠心病的危险因素,HDL是保护性因素。Objective To explorer the epidemiological features and related risk factors of coronary heart disease（ CHD） and evaluate the correlation between aging and CHD. Methods A total of 1 872 patients with coronary angiography by Judkins method were selected and divided into six groups. The severity of coronary artery stenosis,lesion of vascular distribution,basic clinical indexes and Gensini score were compared among group 1（〈 40 years old,n = 64）,group 2（ 40 - 49 years old,n = 208）,group 3（ 50 - 59 years old,n = 492）,group 4（ 60 - 69 years old,n = 554）,group5（ 70 - 79 years old,n = 444） and group 6（ more than 80 years old,n = 110）. The correlations between CHD and age,risk factors were analyzed by Logistic regression analysis. Results The prevalence rates of CHD were 43. 8%（ group 1）,50. 5%（ group 2）,64. 8%（ group 3）,74. 5%（ group4）,79. 7%（ group 5） and 80%（ group 6） respectively. Compared with the patients aged 40 years old,risks of CHD increased by 15%,48%,70%,82% and 83% respectively with the increasing of age of 10 years. Prevalence rate of CHD in male patients was 74. 7%,which was significantly higher than 60. 4% in female patients（ P〈 0. 01）. Three vessel disease,prevalence rate and Gensini score increased with increasing of age. Logistic regression analysis showed that age,gender,smoking,alcohol consumption,hypertension,TC,HDL and UA were independent risk factors for CHD,and HDL is a protective factor. Conclusion With increasing of age,the incidence rate of CHD increases gradually. Male,smoking,hypertension and TC are the risk factors of CHD,while HDL is a protective factor.

关 键 词：冠心病 增龄 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]