单帧单曝光图像法评价粉雾剂吸入装置的分散性能  

Evaluation of Dispersing Performance of Dry Powder Inhalers by Single Frame and Single Exposure Imaging

作　　者：刘阳[1] 陈岚[1] 邹珺[1] 周骛[2] 冯明亮[2] 

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093 [2]上海理工大学能源与动力工程学院,上海200093

出　　处：《中国医药工业杂志》2016年第5期592-596,共5页Chinese Journal of Pharmaceuticals

摘　　要：采用单帧单曝光图像法（single frame and single exposure imaging,SFSEI）同时测定了乳糖（Respitose？SV003）粉末在60 L/min吸入气流作用下、经两种雾化通道（弯折角度为135和90°）分散后的颗粒粒度分布及速度信息。结合Spraytec实时喷雾粒度分析仪和数值模拟方法的测定和计算结果,初步比较和分析了SFSEI测定结果的可靠性。结果表明,SFSEI的测量结果与Spraytec和数值模拟的结果具有较好的相关性,提示该法用于检测吸入装置分散性能是可行的。In this study, the method of single frame and single exposure imaging （SFSE1） was adopted to measure the particle size distribution and particle velocity of lactose （Respitose SV003） powders simultaneously. The powders were atomized in two dispersing channels with bending angles of 135 and 90° at the flow rate of 60 L/min. According to the results of Spraytec particle size measurement system and numerical simulation, the reliability of the results measured by SFSEI was preliminary investigated. The results showed that there was a good correlation between the results measured with SFSEI, Spraytec and numerical simulation. It indicated that SFSEI was feasible for evaluation of dispersing performance of inhalation devices.

关 键 词：单帧单曝光图像法 粉雾剂 吸入装置 分散性能 

分 类 号：O657[理学—分析化学]