新型材料在脉冲释药系统中的应用进展  

Progress of Applications of New Materials to Pulsatile Drug Delivery System

作　　者：王洁敏[1] 王雄飞[1] 王静[1] 方瑜[1] 曹德英[1] 

机构地区：[1]河北医科大学药学院药剂教研室,河北石家庄050017

出　　处：《中国医药工业杂志》2016年第5期643-647,共5页Chinese Journal of Pharmaceuticals

摘　　要：脉冲释药系统具有使药物经预定的时滞后快速或缓控释释放的特点。释药时滞的控制一是依靠外界刺激的触发,另一是依靠制剂本身设定的程序。目前,设计以外界因素刺激来触发脉冲释药的研究日益增多。在查阅近年文献基础上,综述了酶敏感、pH敏感、温度敏感及双敏感等新材料在具有脉冲特性的口服、膜剂、水凝胶和注射剂等给药系统中的应用进展。Drug release profiles of pulsatile drug delivery system （PDDS） can be characterized by a time period of no release （lag time） followed by a rapid or sustained- and controlled-release. Through utilizing triggering signals of external stimulations or formulation itself, the lag time is controlled. Nowadays, the researches on the systems with a triggered release induced by external stimuli are increasing. On the basis of the relevant literatures of recent years, the progress of applications of new materials （such as enzyme-, pH- and temperature-sensitive as well as dual sensitive materials） to oral preparations, films, hydrogels and injections with pulsatile release profiles is reviewed in this paper.

关 键 词：脉冲释药系统 酶敏感 P H敏感 温度敏感 综述 

分 类 号：R94[医药卫生—药剂学]