病毒感染与冠心病相关性的研究  

Correlation between viral infections and coronary heart disease

作　　者：曲振瑞[1] 曲亚丽[1] 吕文艳[1] 武跃明[1] 曲伟峰[1] 

机构地区：[1]南阳市南阳医学高等专科学校护理系,河南南阳473058

出　　处：《中华医院感染学杂志》2016年第9期1990-1992,共3页Chinese Journal of Nosocomiology

基　　金：河南省教育厅科技研究重点基金资助项目(15B320004)

摘　　要：目的探讨冠心病与巨细胞病毒(HCMV)、流感病毒(Ⅳ)、呼吸道合胞病毒(RSV)、单纯疱疹病毒(HSV)、柯萨奇病毒(CoxV)等病毒感染的相关性,为临床防治提供参考。方法选取2014年7月-2015年7月诊治的200例冠心病患者为冠心病组,随机选取同期门诊中老年体检者200名为对照组,以酶联免疫吸附法测定HCMV、Ⅳ、RSV、HSV、CoxV血清IgM抗体进行定性;分析冠心病患者病变严重程度与HCMV、Ⅳ、RSV、HSV、CoxV感染的相关性;采用SPSS17.0统计软件对数据进行统计分析。结果冠心病组患者HCMV、Ⅳ、RSV、HSV、CoxV阳性率均高于对照组,两组比较差异有统计学意义(P<0.05);冠心病组患者2、≥3种病毒感染的感染率均高于对照组,冠心病组1种病毒感染的感染率低于对照组,两组比较差异有统计学意义(P<0.05);冠心病不同分型患者HCMV、Ⅳ、RSV、HSV、CoxV阳性率明显存在不同,心肌梗死患者2、≥3种病毒感染所占比例较多,隐匿性冠心病患者多为单一病毒感染;冠心病患者随着病情加重,HCMV、Ⅳ、RSV、HSV、CoxV检出阳性率明显增高,两者之间呈正相关性(r=0.78、r=0.56、r=0.47、r=0.44、r=0.40,P<0.05)。结论冠心病多存在HCMV、Ⅳ、RSV、HSV、CoxV等病毒感染,以混合感染为主,病毒感染可能是引起冠心病急性发作的诱发因素。OBJECTIVE To explore the correlation between the coronary heart disease and the viral infection induced by human cytomegalovirus（HCMV）,influenza virus（IV）,respiratory syncytial virus（RSV）,herpes simplex virus（HSV）,or coxsackie virus（CoxV）so as to provide guidance for clinical prevention and treatment.METHODS Totally 200 patients with coronary heart disease who were treated in the hospital from Jul 2014 to Jul 2015 were chosen as the coronary heart disease group,meanwhile,200 elderly people who received the physical examination in the outpatient department were set as the control group.The serum IgM antibody of the HCMV,IV,RSV,HSV,and CoxV was quantitatively determined by using enzyme-linked immunosorbent assay,the correlation between the severity of lesion and the HCMV,IV,RSV,or CoxV infection in the patients with coronary heart disease was observed,and the statistical analysis of data was performed with the use of SPSS17.0software.RESULTS The positive rates of HCMV,IV,RSV,and CoxV were higher in the coronary heart disease group than in the control group,and there was significant difference between the two group（P〈0.05）.The incidence rates of viral infections with 2species or no less than three species were higher in the coronary heart disease group than in the control group;the incidence rate of viral infection with 1species was significantly lower in the coronary heart disease group than in the control group,and there was significant difference（P〈0.05）.The positive rates of HCMV,IV,RSV,HSV,and CoxV varied significantly in the patients with different types of coronary heart diseases.The proportion of the myocardial infarction patients with 2species or no less than 3species of viral infections was relatively higher,and most of the patients with occult coronary heart disease had single viral infection.The positive rates of detection of HCMV,IV,RSV,HSV,and CoxV were remarkably increased with the exacerbation of illness,showing positive correlation（r=0.78,r=0.56,r=0.47,r=0.44,r=0.40

关 键 词：冠心病 巨细胞病毒 流感病毒 呼吸道合胞病毒 单纯疱疹病毒 柯萨奇病毒 

分 类 号：R541.4[医药卫生—心血管疾病]