硝苯地平控释片联合缬沙坦治疗对2型糖尿病肾病合并高血压患者血清学指标的影响  

Effect of nifedipine controlled-release tablet combined with valsartan treatment on serological indicators in type 2 diabetic nephropathy patients with hypertension

作　　者：陈松[1] 顾波[2] 王汉清[2] 董蓓晔[2] 易扬[2] 赵颖丹[2] 宣怡[2] 李松杨[2] 马骏[2] 

机构地区：[1]上海市静安区中心医院老年科,上海200040 [2]上海市静安区中心医院肾脏内科,上海200040

出　　处：《海南医学院学报》2016年第13期1398-1401,1405,共5页Journal of Hainan Medical University

基　　金：上海市静安区卫生系统医学科建设特色项目(JWXK201205)~~

摘　　要：目的:分析硝苯地平控释片联合缬沙坦治疗对2型糖尿病肾病合并高血压患者血清学指标的影响。方法:96例2型糖尿病肾病合并高血压患者纳入本次研究,按照临床治疗方案的不同分为硝苯地平组、缬沙坦组及联合治疗组,各32例。治疗后抽取外周静脉血并检测血清肾功能相关指标、肾血管相关指标、病情相关指标值差异。结果:联合治疗组血清胱抑素C(CysC)、同型半胱氨酸(Hcy)、Chemerin、视黄醇结合蛋白4(RBP-4)值均明显低于硝苯地平组及缬沙坦组(P<0.05);联合治疗组血清软骨寡聚基质蛋白(COMP)、凝血酶调节蛋白(TM)、凝血因子Ⅷ(vWF)、微量白蛋白(mALB)值均明显低于硝苯地平组及缬沙坦组(P<0.05),血管生成素-1(Ang-1)、血管生成素-2(Ang-2)值高于硝苯地平组及缬沙坦组(P<0.05);联合治疗组血清胃促生长素(ghrelin)、转化生长因子-β1(TGF-β1)、醛固酮(ALD)值低于硝苯地平组及缬沙坦组(P<0.05),脂联素(APN)及miR-21水平高于硝苯地平组及缬沙坦组(P<0.05)。结论:2型糖尿病肾病合并高血压患者接受硝苯地平控释片联合缬沙坦治疗,可以有效优化病情、抑制肾功能衰竭进展,具有积极的临床意义。Objective：To analyze the effect of nifedipine controlled-release tablet combined with valsartan treatment on serological indicators in type 2diabetic nephropathy patients with hypertension.Methods：A total of 96 cases of type 2diabetic nephropathy patients with hypertension were included in the research,and according to different clinical treatment plans,all patients were randomly divided into nifedipine group,valsartan group and combined treatment group,32 cases in each group.After different treatment,peripheral venous blood was drawn to detect the differences in values of serum renal function-related indicators,renal blood vessel-related indicators and illness-related indexes.Results：Serum Cystatin C（CysC）,homocysteine（Hcy）,Chemerin and retinol binding protein 4（RBP-4）values of combined treatment group were significantly lower than those of nifedipine group and valsartan group（P〈0.05）;serum cartilage oligomeric matrix protein（COMP）,thrombomodulin（TM）,von willebrand factor（vWF）and microalbumin（mALB）values of combined treatment group were significantly lower than those of nifedipine group and valsartan group while angiopoietin-1（Ang-1）and angiopoietin-2（Ang-2）values were higher than those of nifedipine group and valsartan group（P〈0.05）;serum Ghrelin,transforming growth factor-β1（TGF-β1）and aldosterone（ALD）values of combined treatment group were significantly lower than those of nifedipine group and valsartan group while adiponectin（APN）and miR-21 values were higher than those of nifedipine group and valsartan group（P〈0.05）.Conclusions：Nifedipine controlled-release tablet combined with valsartan treatment of type 2diabetic nephropathy patients with hypertension can effectively optimize the illness and inhibit the progression of renal failure,and it has positive clinical significance.

关 键 词：2型糖尿病肾病 高血压 硝苯地平 缬沙坦 

分 类 号：R587.2[医药卫生—内分泌]