医用高分子材料降解的原位探测方法  

Methodology of in situ Detection of Degradation of Polymeric Biomedical Materials

作　　者：齐永丽[1] 雷科文 俞麟[1] 丁建东[1] 

机构地区：[1]聚合物分子工程国家重点实验室,复旦大学高分子科学系,上海200433

出　　处：《高分子通报》2016年第5期43-51,共9页Polymer Bulletin

基　　金：国家自然科学基金(No.51533002);上海市科技发展基金(No.14JC1490400)资助

摘　　要：可降解高分子材料在骨科内固定、药物缓控释载体、组织工程支架、心血管支架等领域均有重要应用。为使材料的降解速率、力学性能与实际应用之间相匹配,需要对材料的降解行为有清晰的了解。早期对材料降解行为的研究主要采取定期取样测质量变化等方法,需消耗大量的样品和动物。为解决这个问题,一些新型成像技术被用于原位探测材料的降解行为,从而实现对同一个样品的连续监测。本文综述了近年来采用原位法研究可降解高分子材料降解行为的进展情况,侧重荧光成像法、光声及超声成像法和电化学方法。Biodegradable polymers are widely applied in medicine such as orthopedic internal fixation, controlled/ sustained drug release, tissue engineering scaffolds, and cardiovascular stents. Appropriate biodegradation is critical for those medical applications. A classical detection of biodegradation requires a large number of material samples and animals. Alternatively, some imaging techniques have been explored for non-invasive assessment of the degradation profile of an individual sample in situ. This review summarizes the recent advances in the field of in situ and non-invasive characterization of biodegradable polymeric materials, with emphasis of fluorescence imaging, photoacoustic/ultrasound imaging, and electrochemical method.

关 键 词：医用高分子 生物可降解 荧光成像法 光声及超声成像法 电化学方法 

分 类 号：R318.08[医药卫生—生物医学工程]