徐氏验方内服外敷治疗心脾积热型小儿疱疹性口炎的临床研究  

Clinical research on internal and external treatment for childhood herpetic stomatitis of heartspleen accumulated heat by Xu Xiao-pu's empirical formula

作　　者：胡心怡[1] 李冰[1] 陈红娟[1] 姜之炎[2,3] 陆鸿元[3,4] 陆城华 

机构地区：[1]复旦大学附属儿科医院口腔科,上海201102 [2]上海中医药大学附属龙华医院儿科,上海200032 [3]上海中医药大学附属龙华医院徐小圃学术思想研究室,上海200032 [4]上海中医药大学附属龙华医院内科,上海200032

出　　处：《上海中医药杂志》2016年第5期51-54,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市卫计委海派中医流派传承研究工程"徐氏儿科"项目(ZYSNXD-CC-HPGC-JD005)

摘　　要：目的观察徐氏验方内服外敷治疗心脾积热型小儿疱疹性口疮的临床疗效。方法将60例心脾积热型小儿疱疹性口疮患儿随机分为治疗组与对照组,每组30例。对照组予利巴韦林气雾剂联合蒲地蓝口服液,治疗组予徐氏清热泻脾散内服及徐氏金不换口疮散外敷。两组疗程均为6天,观察临床疗效及安全性,比较临床症状的缓解时间。结果 1治疗组、对照组总有效率均为100%,临床痊愈率分别为66.67%和46.67%;组间临床疗效比较,差异有统计学意义(P<0.05)。2组间治疗期间比较,疱疹消退、非正常进食水及发热的天数均有统计学意义(P<0.05),而在流涎天数无统计学意义(P>0.05)。3两组患儿均未出现明显不良反应。结论徐氏验方内服外敷治疗心脾积热型小儿疱疹性口疮的疗效较佳,可较快缓解患儿临床症状,减轻痛苦。Objective To observe the effects of Xu Xiao-pu＇ s empirical formula in the internal and external treatment for herpetic stomatitis in children with syndrome of accumulated heat in heart and spleen. Methods Sixty subjects were randomly divided into treatment group and control group, 30 cases in each group. The patients in control group were treated with Ribavirin Aerosol combined with Pudilan oral liquid, and the treatment group were treated with Xu Xiao-pu＇ s empirical formula via internal and external application. Two groups were treated for 6 days. Clinical efficacy and safety were observed, and the time for clinical symptoms relief was compared. Results （1）After treatment for 6 days, the total effective rate was 100% in both groups. The clinical cure rates were 66.67% in the treatment group and 46.67% in the control group, with significant difference between the two groups （ P 〈 0.05 ）. （2）Compared between two groups, the occurrence of herpes regression, abnormal diet and fever symptoms were significantly different （ P 〈 0.05 ）, but there was no significant difference in the time of salivation （ P 〉 0.05 ）. （3）There were no obvious adverse reactions in two groups. Conclusion Xu Xiao-pu＇ s empirical formula in internal and external treatment is quite effective far herpetic stomatitis in children with syndrome of accumulated heat in heart and spleen, and relieve clinical symptoms.

关 键 词：疱疹性口炎 小儿 口疮 心脾积热证 清热泻脾散 金不换口疮散 徐小圃 

分 类 号：R276.8[医药卫生—中医五官科学]