中药治疗奶牛乳房炎的系统评价与Meta分析  

Systematic evaluation and meta-analysis on efficacy of Chinese herbal medicine on cow mastitis

作　　者：杨健[1,2] 严作廷[1] 王东升[1] 张世栋[1] 杨志强[1] 董书伟[1] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所/农业部兽用药物创制重点实验室/甘肃省新兽药工程重点实验室,兰州730050 [2]北京农学院动物科学技术学院,北京102206

出　　处：《南方农业学报》2016年第4期656-663,共8页Journal of Southern Agriculture

基　　金：国家科技支撑计划项目(2012BAD12B03);国家自然科学基金项目(31302156);中央级基本科研业务费预算增量项目(2014ZL012)

摘　　要：【目的】利用Meta分析方法对已发表的中药治疗奶牛乳房炎临床试验研究进行系统评价,为防治奶牛乳房炎提供更有价值的参考依据。【方法】通过计算机检索中国知网(CNKI)和万方数据库,检索时限均为从建库起至2015年4月,全面收集中药治疗奶牛乳房炎的临床试验研究。按照Cochrane方法纳入文献,采用Rev Man 5.3软件进行Meta分析。【结果】共纳入26篇文献,3419头患病牛,其中试验组2481例,对照组938例,试验组均采用中药治疗,对照组采用青链霉素治疗。复方中药治疗牛乳房炎的总治愈率显著高于青链霉素对照组[OR=2.03,95%CI(1.56,2.63),P<0.05],总有效率显著高于青链霉素对照组[OR=2.25,95%CI(1.57,3.22),P<0.05],乳区总治愈率高于青链霉素对照组[OR=1.54,95%CI(1.43,1.66),P<0.05],乳区总有效率极显著高于青链霉素对照组[OR=1.20,95%CI(1.15,1.26),P<0.01]。发表偏倚分析结果显示,所纳入文献存在一定的发表偏倚性。【结论】复方中药对奶牛乳房炎的疗效显著优于青链霉素,即奶牛乳房炎的中药防治研究存在重要潜力。[Objective]The published clinical trial about treatment of cow mastitis with Chinese herbal medicine were systemically evaluated by meta-analysis method, in order to provide valuable reference for treatment of cow mastitis. [Method]The clinical randomised controlled trials（RCTs） about treatment of cow mastiffs with Chinese herbal medicine were searched completely from databases of CNKI and WANFANG DATA. According to Cochrane system instruction, meta- analysis was conducted by using RevMan 5.3 software. [Result]A total of 26 RCTs and 3419 diseased cows were included, a- mong them, 2481 cows in treatment group treated with Chinese herbal medicine, 938 cows in control group treated with penicillin-stretomycin. In addition, The cure rate of total cow number in Chinese herbal medicine group was significantly higher than that in penicillin-stretomycin group[OR=2.03, 95% CI（1.56, 2.63）, P〈0.05]. The effective rate of total cows number in Chinese herbal medicine group was significantly higher than that in penicillin-stretomycin group [OR=2.25, 95% CI（1.57,3.22）, P〈0.05 ]. The cure rate of total breast area number in Chinese herbal medicine group was higher than that in penicillin-stretomycin group[OR=l.54, 95% CI（1.43, 1.66）, P〈0.05 ]. The effective rate of total breast area number in Chinese herbal medicine group was higher than that in peniciUin-stretomycin group [OR=l.20, 95% CI （1.15, 1.26）, P〈0.01 ]. The analysis results of publication bias showed that the included literatures had some certain bias. [Conclusion] Chinese herbal medicine has more significant curative effect on cow mastiffs than penicillin-streptomycin.

关 键 词：奶牛 乳房炎 META分析 中药 青链霉素 

分 类 号：S858.232.6[农业科学—临床兽医学]