继发性不孕不育女性生殖道支原体与沙眼衣原体的感染分析  

Prevalence of genital tract Mycoplasmaand Chlamydia trachomatis infections in female patients with secondary infertility

作　　者：王琦[1] 张红云[1] 陈蔚清[1] 张勇[1] 张程[1] 

机构地区：[1]贵州省人民医院生殖中心,贵州贵阳550002

出　　处：《中华医院感染学杂志》2016年第10期2348-2350,共3页Chinese Journal of Nosocomiology

基　　金：贵州省科技攻关基金资助项目(SY20103081)

摘　　要：目的探究继发性不孕不育女性生殖道支原体和沙眼衣原体的感染情况,为女性继发性不孕不育的临床防治提供相关指导。方法选择2012年9月-2015年9月医院收治的100例不孕不育女性为研究对象,将其中48例继发性不孕不育患者设为观察A组,52例原发性不孕不育患者设为观察B组,并选取50名正常生育者为对照组,分析3组人员解脲脲支原体、人支原体和沙眼衣原体的感染及常规抗菌药物的药敏性,使用SPSS18.0软件对数据进行统计分析。结果观察A组和观察B组沙眼衣原体、解脲脲支原体、人支原体、解脲脲支原体+人支原体、沙眼衣原体+解脲脲支原体的感染率均高于对照组,差异有统计学意义(P<0.05);观察A组沙眼衣原体和解脲脲支原体的感染率显著高于观察B组,差异有统计学意义(P<0.05);氧氟沙星对沙眼衣原体、解脲脲支原体和人支原体耐药率较高,分别为36.0%、37.5%、35.3%,交沙霉素和多西霉素对沙眼衣原体、解脲脲支原体和人支原体耐药率较低,分别为4.0%、2.5%、5.9%和0、2.5%、5.9%。结论女性生殖道支原体和沙眼衣原体感染是造成女性继发性不孕不育的重要因素,应积极做好感染防治工作,降低女性继发性不孕症的发生率。OBJECTIVE To investigate the prevalence of genital tract Mycoplasmaand Chlamydia trachomatis infections in female patients with secondary infertility so as to provide guidance for clinical prevention and treatment of the secondary infertility.METHODS A total of 100 infertility women who were treated in the hospital from Sep2012 to Sep 2015 were recruited as the study objects,then 48 patients with secondary infertility were assigned as the observation group A,52 patients with primary infertility were set as the observation group B,and 50 normal fertility women were chosen as the control group.The prevalence rates of Ureaplasma urealyticum,Mycoplasma hominis,and C.trachomatis infections and the drug susceptibility to the commonly used antibiotics were observed and compared among the three groups of participants,and the statistical analysis of data was performed with the use of SPSS18.0software.RESULTS The incidence rates of Ct,Uu,Mh,Uu plus Mh,and Ct plus Uu infections were significantly higher in the observation group A and the observation group B than in the control group（P〈0.05）.The incidence rates of Ct and Uu infections of the observation group A were significantly higher than those of the observation group（P〈0.05）.The drug resistance rates of Ct,Uu,and Mh to ofloxacin were 36.0%,37.5%,and 35.3%,respectively.The drug resistance rates of Ct,Uu,and Mh to josamycin were 4.0%,2.5%,and 5.9%,respectively;the drug resistance rates of Ct,Uu,and Mh to doxycycline were 0,2.5%,and 5.9%,respectively.CONCLUSIONThe genital tract Mycoplasma and Ct infections are the leading factors that result in the secondary infertility of the female.It is necessary to take prevention measures so as to reduce the incidence of secondary infertility of the female.

关 键 词：继发性不孕不育 女性 生殖道感染 支原体属 沙眼衣原体 

分 类 号：R374.3[医药卫生—病原生物学]