小儿肺炎患儿血清CK、cTnT水平及心电图变化特征在疾病治疗及预后评价中的应用研究  

Research of Application of Serum CK,CTnT Level and ECG Change Features in the Treatment and Prognosis of Children with Pneumonia

作　　者：王洪洲[1] 祝介云[1] 白士丽[2] 

机构地区：[1]临朐县人民医院儿科,山东临朐262600 [2]临朐县人民医院检验科,山东临朐262600

出　　处：《医学综述》2016年第9期1821-1823,共3页Medical Recapitulate

摘　　要：目的分析小儿肺炎患儿血清中肌酸激酶(CK)、心肌肌钙蛋白T(c Tn T)的水平及心电图的变化特征在疾病治疗及预后评价中的应用。方法选取2014年2月至2015年3月临朐县人民医院收治的142例肺炎患儿作为研究对象,按照病情轻重程度分为轻症组(82例)和重症组(60例),同时选取60例正常的小儿作为对照组。对观察组肺炎患儿治疗前后和对照组小儿血清中CK和c Tn T的活性进行对比分析,并采用床边常规性心电图对两组受试者心电图的变化特征进行记录。结果治疗前,重症组CK、c Tn T水平高于轻症组和对照组,差异均有统计学意义(P<0.05);治疗后,轻症组和重症组CK、c Tn T水平低于治疗前,轻症组和重症组CK、c Tn T水平高于对照组,差异均有统计学意义(P<0.05)。治疗前,轻症组和重症组窦性心动过速、束支传导阻滞、P波高尖发生率高于对照组(P<0.05);治疗后,轻症组和重症组窦性心动过速、房性期前收缩发生率低于治疗前(P<0.05);治疗前,重症组P-R或QT间期延长、ST段抬高或压低、T波低平或倒置发生率高于对照组和轻症组(P<0.05)。结论小儿肺炎患儿的血清中CK和c Tn T水平明显较高,同时其心电图也发生了特征性变化,随着患儿肺炎病程的加深,其心肌的损伤程度也更严重。将三者联合在疾病的治疗及预后评价中具重要的意义。Objective To analyze the application of serum creatine kinase （CK） ,the levels of cardiac troponin T（cTnT） and electrocardiogram（ECG） change features in disease treatment and prognosis evalua- tion of children with pneumonia. Methods Total of 142 children with pneumonia in Linqu People＇s Hospital from Feb. 2014 to Mar. 2015 were irrluded in the study, and according to the illness severity they were divided into two groups, namely the mild group （82 cases） and severe group （60 cases ）, another 60 normal children were inlcuded as the control group. The CK and cTnT before and after the treatment of children with pneumo- nia and the control group were analyzed, and the bed routine ECG was used for recording characteristics changes of both groups. Results Before treatment, CK, cTnT level in the severe group were higher than the mild group and control group, the differences were statistically significant （ P 〈 0. 05 ） ; after treatment, CK, cTnT in the mild group and severe group were lower than before treatment, and CK, cTnT level in the mild group and severe group were higher than the control group,the differences were statistically significant（ P 〈 0. 05 ）. Before treatment, sinus tachycardia, bundle branch block, P wave-occurrence rate in the mild group and severe group were higher than the control group （P 〈 0. 05 ） ;after treatment, sinus tachycardia, atrial con- traction in the mild group and severe group were lower than before treatmen （ P 〈 0. 05 ） ; before treatment, P- R or QT prolongation,ST segment elevation or depression, T wave flat or inversion incidence in the severe group were higher than the mild group and control group（P 〈0. 05）. Conclusion Serum CK and cTnT lev- el in children with pneumonia are obviously higher, and the ECG features are also changed; as the progression of pneumonia, the myocardial damage is aggravated. The combination of the three indexes has great signifi- cance for the treatment and prognosis assessment of the disease.

关 键 词：小儿肺炎 肌酸激酶 心肌肌钙蛋白T 心电图 疾病治疗 预后 

分 类 号：R725[医药卫生—儿科]