胸主动脉腔内修复术对急性主动脉夹层破裂肺损伤患者炎性细胞因子的影响  

The Effect of Thoracic Aortic Endovascular Repair of Acute Aortic Dissection Ruptured Lung Injury and Inflammatory Cytokines

作　　者：李祥[1] 姚碧[1] 倪良春[1] 李庆臣[1] 马黎明[1] 刘高利[1] 

机构地区：[1]济宁医学院附属医院心血管外科,山东济宁272029

出　　处：《医学综述》2016年第9期1851-1854,共4页Medical Recapitulate

摘　　要：目的探讨胸主动脉腔内修复术对急性主动脉夹层破裂肺损伤患者炎性细胞因子的影响。方法选择2013年3月至2015年3月济宁医学院附属医院接诊的急性主动脉夹层破裂肺损伤患者60例作为研究对象,依据随机数字表法分为观察组和对照组,各30例。对照组采取药物治疗,观察组在药物治疗基础之上采用胸主动脉腔内修复术。对比分析两组患者的术前临床情况、炎性细胞因子及临床疗效。结果治疗后观察组患者的白细胞介素(IL)-6、IL-8、肿瘤坏死因子α(TNF-α)均低于对照组[(13±5)ng/L比(26±13)ng/L;(44±14)ng/L比(66±26)ng/L;(10±3)ng/L比(26±11)ng/L],且均低于治疗前[(68±23)ng/L、(96±16)ng/L、(42±11)ng/L],差异有统计学意义(P<0.05)。观察组总有效率为100.0%(30/30),高于对照组的73.3%(22/30),差异有统计学意义(P<0.05)。结论胸主动脉腔内修复术治疗急性主动脉夹层破裂肺损伤的效果良好,值得临床广泛推广和应用。Objective To analyze and discuss the effect of thoracic aortic endovascular repair on acute aortic dissection ruptured lung injury and inflammatory cytokines. Methods Total of 60 cases of acute aortic dissection ruptured lung injury admitted to Jining Medical College Affiliated Hospital from Mar. 2013 to Mar. 2015 were included in the study. They were divided into observation group and control group according to random number table method, 30 eases each. The control group adopted medication, while the observation group was added thoracic aortic endovascular repair. The general clinical information before treatment,inflam- matory cytokines and clinical efficacy of the two groups were comparatively analyzed. Results The interleu- kin（IL） -6, IL-8, tumor necrosis factor α （TNF-α） of the observation group after treatment were lower than the control group[ （13 ± 5 ） ng/L vs （26 ± 13 ） ng/L; （44 ± 14） ng/L vs （66 ± 26） ng/L; （10 ± 3 ） ng,/L vs （ 26 ± 11 ） ng/L ], and lower than before treatment [ （68 ± 23 ） ng/L, （96 ± 16 ） ng/L, （42 ± 11 ） ng/L ], the differenees were statistically significant （ P 〈 0. 05 ）. The total effeetive rate of the observation group was higher than the control group [ 100. 0% （30/30） ,73.3% （22/30） ] ,the difference was statistically signifi- cant （P 〈 0. 05 ）. Conclusion Thoracic aortic endovascular repair of acute aortic dissection ruptured lung injury has good effect, thus is worthy of wider promotion and applieation in elinieal.

关 键 词：急性主动脉夹层破裂 肺损伤 胸主动脉腔内修复术 炎性细胞因子 

分 类 号：R563[医药卫生—呼吸系统]