龙胆泻肝胶囊对肝胆湿热型分泌性中耳炎患者PAF,ET-1含量的影响  

Effect of Longdan Xiegan Capsule on Platelet Activating Factor and Endothelin-1 Levels in Patients with Secretory Otitis Media of Liver and Gallbladder Dampness-Heat Type

作　　者：文凤妮 黄文柱 陆扬光 刘小晶 朱原[2] 李灼宏 张继平[3] 

机构地区：[1]佛山市第五人民医院,广东佛山528000 [2]南方医科大学中医药学院,广州510515 [3]南方医科大学附属佛山医院,广东佛山528000

出　　处：《中国实验方剂学杂志》2016年第10期158-161,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：佛山市医学类科技攻关项目(201208079)

摘　　要：目的:探讨龙胆泻肝胶囊对肝胆湿热型分泌性中耳炎患者血清和积液中血小板活化因子(PAF)与内皮素-1(ET-1)含量的影响。方法:选取60例佛山市第五人民医院门诊诊断为肝胆湿热型分泌性中耳炎患者,按随机数字表法分为对照组与试验组,各30例,两组治疗前抽取患者静脉血并保留中耳积液,经离心后保存于-80℃冰箱保存。对照组采用鼓膜穿刺,并予头孢克洛缓释胶囊联合氯雷他定片口服治疗,试验组采用鼓膜穿刺,并予龙胆泻肝胶囊口服;治疗7 d后再次抽取患者静脉血离心保存,评价临床疗效并测量血清及积液中PAF与ET-1含量。结果:治疗组总体疗效优于对照组(P<0.05),与对照组比较,治疗组再次穿刺治疗抽出积液率较低(P<0.05);与治疗前比较,两组治疗后血清与积液中PAF,ET-1含量均明显降低(P<0.05),其中以龙胆泻肝胶囊效果更显著。结论:龙胆泻肝胶囊治疗分泌性中耳炎的作用显著,其机制可能与抑制PAF,ET-1表达有关。Objective： To explore the effect of Longdan Xiegan capsules on platelet activation factor（ PAF） and endothelin-（-1）（ ET-1） levels in patients with secretory otitis media of liver and gallbladder dampnessheat type. Method： The 60 patients with secretory otitis media of liver and gallbladder dampness-heat type in Foshan Fifth People＇s Hospital were divided into control group and experimental group according to the random number table method,30 cases in each group. The samples of venous blood were taken before treatment,and middle ear effusion of patients was stored at- 80 ℃ in refrigerator after centrifugation. Patients in control group were treated with the tympanic membrane puncture and cefaclor capsules combined with loratadine tablets by oral administration, while patients in experimental group were treated with the tympanic membrane puncture and Longdan Xiegan capsules by oral administration. After 7 days treatment,the venous blood of patients was collected again,clinical efficacy was evaluated and PAF and ET-1 levels in serum and effusion were determined. Result：The total clinical efficacy of experimental group was better than that of control group（ P〈0. 05）,with a lower rate of effusion extraction after re-puncturing in experimental group（ P〈0. 05）. There was no significant difference in PAF and ET-1 levels in serum and effusion between control group and experimental group before treatment. The PAF and ET-1 levels in serum and effusion in both groups were significantly reduced after treatment（ P〈0. 05）,and Longdan Xiegan capsules had a more significant effect than the control group. Conclusion： Longdan Xiegan capsules had significant effect in the treatment of secretory otitis media, and its mechanism may be related to inhibiting the expression levels of PAF and ET-1.

关 键 词：分泌性中耳炎 龙胆泻肝胶囊 血小板活化因子 内皮素-1 

分 类 号：R287[医药卫生—中药学]