新生儿维生素D与血浆胰岛素及血糖水平的相关性研究  

Correlation between vitamin D with fasting plasma insulin and blood glucose in neonates

作　　者：王爱萍[1] 李杨方[1] 柴琳[1] 吴玉芹[1] 陶娜[1] 杨汝文[1] 赵晓芬[1] 邱丽玲[1] 

机构地区：[1]昆明市儿童医院,云南昆明650228

出　　处：《中国儿童保健杂志》2016年第5期469-471,共3页Chinese Journal of Child Health Care

基　　金：昆明市2012年科技计划项目(2012-04-01-A-S-02-1014)

摘　　要：目的研究新生儿血清维生素D(VitD)是否与空腹血浆胰岛素(INS)、C肽(CP)及血糖(GLU)水平之间存在相关性。方法选取100例新生儿作为研究对象(其中足月儿58例,早产儿42例),检测血清25-羟基维生素D2[25(OH)D2]、血清25-羟基维生素D_3[25(OH)D_3]、血清25-羟基维生素D[25(OH)D]、空腹血浆胰岛素(INS)、C肽(CP)及血糖(GLU)浓度,采用SPSS 17.0对数据进行独立样本t检验和Pearson相关分析。结果足月儿组血清25(OH)D_3、25(OH)D、空腹血浆INS、CP、空腹GLU浓度高于早产儿组,差异有统计学意义(P<0.05)。足月儿血清25(OH)D_3、25(OH)D与空腹血浆INS、CP呈正相关(r=0.515,0.324,0.523,0.335,P<0.05或<0.01),与空腹GLU呈负相关(r=-0.489,-0.514,P均<0.01)。早产儿血清25(OH)D_3、25(OH)D与空腹血浆INS、CP呈正相关(r=0.509,0.367,0.598,0.432,P<0.05或<0.01),与空腹GLU呈负相关(r=-0.539,-0.587,P均<0.01)。结论新生儿期血清VitD与空腹血浆INS、CP呈正相关,与空腹血糖呈负相关。Objective To explore correlation between vitamin D with fasting plasma insulin,C-Peptide and blood glucose. Method The concentrations of serum 25-hydroxyvitamin D2125（OH）D2],25-hydroxycholecalciferol[25（OH）D3], 25-hydroxyvitamin D[25 （OH） D], fasting plasma insulin（INS）, C-Peptide （CP） and blood glucose （GLU） were measured in 58 full-term infants and 42 preterm infants,and the data were statistically analyzed by SPSS 17.0 software. Results The 25（OH）D3,25（OH）D,INS,CP and GLU in group of full-term infants were higher than those in group of preterm infants（P 〈0.05）. Levels of serum 25 （OH） D3,25 （OH） D in full-term infants had positive correlations with INS, CP （r = 0. 515, 0. 324,0. 523,0. 335,PG0.05 or GO. 01）,and negative correlations with GLU（r=--0. 489,--0. 514,all P〈0.01）. Levels of serum 25 （OH）Do, 25 （OH）D in preterm infants had positive correlations with INS, CP （r= 0. 509,0. 367,0. 598,0. 432, P 〈0.05 or 〈0.01） ,and negative correlations with GLU（r= -0. 539, -0. 587 ,all P〈0.01）. Conclusion Levels of serum 25-hydroxyvitamin D in neonates have positive correlations with fasting plasma insulin and C-Peptide,and negative correlations with blood glucose.

关 键 词：新生儿 足月儿 早产儿 维生素D 胰岛素 C肽 血糖 

分 类 号：R179[医药卫生—妇幼卫生保健]