改性木质素磺酸钠水凝胶对阿魏酸哌嗪的缓释作用研究  

SUSTAINED RELEASE OF FERULIC ACID PIPERAZINE FROM MODIFIED LIGNOSULFONATE HYDROGEL

作　　者：姚奋尖 向育君[1,2] 冯伟[1] 陈丽娟[1] 

机构地区：[1]湖南科技大学生命科学学院,湘潭411201 [2]重金属污染土壤生态修复与安全利用湖南省高校重点实验室,湘潭411201

出　　处：《离子交换与吸附》2016年第2期134-140,共7页Ion Exchange and Adsorption

基　　金：国家自然科学基金资助项目(21406058);湖南省科学技术厅资助项目(2014NK3060)

摘　　要：使用改性木质素磺酸钠水凝胶在室温下吸附包埋药物阿魏酸哌嗪,并在干燥温度分别为20℃、40℃和70℃时制备了载药干凝胶,并研究了上述载药干凝胶在p H值分别为7.4和1.4的缓冲溶液中对阿魏酸哌嗪的缓释作用。研究表明,改性木质素磺酸钠水凝胶对阿魏酸哌嗪具有缓释作用,低温下干燥制备的载药干凝胶的释药速率更加平缓,酸性条件下释药速率低。In this paper, drug-loaded xerogel was prepared by adsorption and entrapment of ferulic acid piperazine in modified sodium lignosufonate hydrogel at room temperature and subsequent drying at 20℃, 40℃ and 70℃, respectively. The experiments of drug release in buffer solution were also investigated at different pH value of 7.4 and 1.4, and the results indicated that modified sodium lignosufonate hydrogel had good sustained release effect for ferulic acid piperazine, the drug-loaded xerogel dried under low-temperature displayed a gentler drug release curve and a lower drug release rate under acidic condition.

关 键 词：改性木质素磺酸钠水凝胶 阿魏酸哌嗪 缓释 

分 类 号：TQ424.3[化学工程]