吡唑羧酸类金属配合物的合成、晶体结构及其与牛血清白蛋白的相互作用  

Syntheses,Crystal Structures and Interaction with Bovine Serum Albumin of Pyrazole Carboxylic Acid of Metal Complexes

作　　者：张秀清[1] 范超逸 倪萌[1] 李璇[1] 韦华传 

机构地区：[1]桂林理工大学化学与生物工程学院广西电磁化学功能物质重点实验室,广西桂林541004

出　　处：《化学试剂》2016年第5期409-413,432,共6页Chemical Reagents

基　　金：广西高校科学技术研究项目(2013YB116);广西药用资源化学与药物分子工程重点实验室;教育部重点实验室资助项目(CMEMR2012-B06)

摘　　要：以吡唑-3-甲酸、吡唑-4-甲酸为配体,采用溶液法分别与Cu Cl_2·2H_2O、Zn(NO_3)_2·6H_2O反应,合成了两种金属配合物并通过IR、X-射线单晶衍射仪对其晶体结构进行了表征。利用紫外-可见吸收光谱和荧光光谱研究了它们与牛血清白蛋白(BSA)的相互作用。实验结果表明,配合物与BSA发生强烈的结合,这些研究为人类研究药物分子与BSA相互作用的机理提供有价值的信息。Two new complexes have been synthesized by solvent method using pyrazole-3-carboxylic acid and pyrazole-4-carboxylie acid as ligands reacting with CuC12.2H20 and Zn（ NO3 ）2 ·6H2O metal salts. The two complexes were confirmed by infrared spectroscopy and its structures were measured by single-crystal X-ray diffraction. The interaction between complexes and BSA was investigated by UV-Vis spectra and fluorescence spectroscopy. The results showed that the reaction between complexes and BSA were exquisite. This work will be beneficial for people to study the mechanism of the interaction between drug molecule and BSA.

关 键 词：金属配合物 晶体结构 牛血清白蛋白 

分 类 号：O799[理学—晶体学]