内质网应激在糖尿病肾病发病机制中的研究进展  

Research progress of endoplasmic reticulum stress in pathogenesis of diabetic nephropathy

作　　者：刁宗礼[1,2] 郭维康[1,2] 刘文虎[1,2] 

机构地区：[1]首都医科大学附属北京友谊医院肾内科,北京100050 [2]首都医科大学肾病学系,北京100050

出　　处：《兰州大学学报（医学版）》2016年第2期76-80,共5页Journal of Lanzhou University（Medical Sciences）

基　　金：国家自然科学基金项目(81300607);北京市科技计划项目(D131100004713001)

摘　　要：内质网应激与糖尿病密切相关,糖尿病肾病是糖尿病的重要并发症,因此内质网应激在糖尿病肾病中的作用越来越受到重视。近年来研究表明,内质网应激与糖尿病肾病巾肾脏足细胞、内皮细胞、系膜细胞和肾小管上皮细胞的损伤均相关。Diabetic nephropathy is one of the most important complications of diabetes which is closely related to endoplasmic reticulum stress. Recent studies suggested that endoplasmic reticulum stress is closely related to the injury of renal podocytes, endothelial cells, mesangial cells and tubular epithelial cells in diabetic nephropathy. This article reviewed the relationship between endoplasmic reticulum stress and diabetic nephropathy.

关 键 词：内质网应激 糖尿病肾病 糖尿病 

分 类 号：R318.16[医药卫生—生物医学工程]