神经节苷脂治疗小儿手足口病并中枢神经系统损害的疗效观察  

Observation on the efficacy of children with HFMD and central nervous system damage treated wtih ganglioside

作　　者：徐良斌[1] 

机构地区：[1]四川双流县中医医院,双流610200

出　　处：《中国实用神经疾病杂志》2016年第7期10-12,共3页Chinese Journal of Practical Nervous Diseases

基　　金：四川省卫生局创新计划项目(编号:20142777118)

摘　　要：目的观察神经节苷脂治疗小儿手足口病并中枢神经系统损害的临床疗效。方法 85例患儿随机分为治疗组与对照组,对照组采用常规治疗加胞二磷胆碱注射液静滴,治疗组在对照组基础上加单唾液酸四己糖神经节苷脂注射液静滴,均治疗7d。根据患儿精神症状、体温、皮疹、血常规检查及脑电图恢复情况进行疗效评定,详细记录2组主要症状消失时间、病程及住院时间、神经元特异性烯醇化酶(NSE)水平。结果治疗组总有效率83.72%,对照组为64.28%,差异有统计学意义(Z=1.981,P<0.05);治疗后治疗组NSE水平(19.78±4.25)μg/L,对照组为(28.45±4.17)μg/L,差异有统计学意义(t=9.491,P<0.05);治疗组脑电图恢复正常率60.47%,明显高于对照组的38.00%(χ2=4.253,P=0.032);治疗组发热、惊跳、肢体抖动消失时间、病程及住院时间均较对照组明显缩短,差异有统计学意义(P<0.05)。结论小儿手足口病并中枢神经系统损害给予神经节苷脂治疗,可明显改善或消除患儿神经系统症状,提高疗效,缩短病程。Objective To observe the clinical efficacy of ganglioside for children with HFMD and central nervous system damage. Methods Eighty five patients were randomly divided into treatment group and control group, the control group re- ceived conventional therapy plus citicoline intravenous injection, the treatment group received monosialo four hexose ganglio- side injections based on the control group, all the patients were treated for 7 days. According to children with psychiatric symptoms, body temperature, skin rash, blood tests and EEG recovery, the efficacy was evaluated. In the two groups, the main symptoms disappearing time, duration and hospital stay and neuron-specific enolase levels were recorded. Results The to- tal effective rate was 83.72 % in the treatment group, which was 64.28 % in the control group, the difference was statistically significant between the two groups（Z=1. 981, P〈0.05）; after treatment, neuron-specific enolase level in the treatment group was （19.78±4.25）μg/L, which was （28.45±4. 17）μg/L the control group, the difference was statistically significant between the two groups（t=9. 491, P〈0.05） ; treatment group returned to normal EEG was 60.47%, which was sigrlificantly higher than 38.00 % in the control group（z2 = 4. 253, P = 0. 032） ; the fever, startle, limb shaking disappearing time, duration and hospital stay were significantly shorter than those of control group, the differences were statistically significant （P〈 0.05）. Conclusion Children with HFMD and central nervous system damage treated by ganglioside can significantly improve or eliminate the symptoms of nervous system, improve the efficacy and shorten the course.

关 键 词：神经节苷脂 手足口病 小儿 神经系统损害 

分 类 号：R512.5[医药卫生—内科学]