吡啶酰胺类化合物的合成及其除草活性  

Synthesis and Herbicidal Activity of Several Pyridine Amides Derivatives

作　　者：霍静倩[1] 张静[2] 张哲[1] 张金林[1] 

机构地区：[1]河北农业大学植物保护学院,河北保定071000 [2]农业部农药检定所,北京100025

出　　处：《农药》2016年第5期328-330,346,共4页Agrochemicals

基　　金：国家自然科学基金资助项目(31171877)

摘　　要：[目的]寻求新的含吡啶环的具有除草活性的先导化合物。[方法]以3-氟-4-甲基苯胺和几种吡啶甲酸衍生物进行缩合反应,得到9个未见文献报道的吡啶酰胺类化合物1a^1i,其中有3个是新化合物。[结果]所得化合物结构经~1H NMR和MS确认。[结论]初步生物活性测定表明:1000 mg/L质量浓度下,所有目标化合物均表现出了除草活性,其中化合物1b、1c、1d和1e的除草效果较好,化合物1b对靶标抑制率几乎达到100%。[Aims] The study aims to search for new lead compounds possessing herbicide activities containing pyridine ring. [Methods] Nine unreported pyridine amides derivatives la - li, of which three were new, were prepared by a condensation reaction of 3-fluoro-4-methyl aniline and substituted pyridine carboxylic acid. [Results] Their structures were confirmed by JH NMR and MS spectra. [Conclusions] Preliminary biological activity results showed that all of compounds displayed herbicidal activities at the concentration of 1000 mg/L. Wherein the compounds lb, lc, ld and le showed better herbicidal activity, and the inhibition rate of lb to target almost reached 100%.

关 键 词：吡啶甲酸衍生物 3-氟-4-甲基苯胺 合成 除草活性 

分 类 号：TQ450.1[化学工程—农药化工]