注射用盐酸多西环素致静脉炎3例及不良反应文献复习  

Literature Review of Doxycycline Hyclate for Injection Induced Phlebitis in 3 Adverse Reactions Cases

作　　者：吴蔚[1] 蓝茜榆 

机构地区：[1]广西壮族自治区人民医院,广西南宁530021 [2]广西医科大学药学院,广西南宁530021

出　　处：《中国药业》2016年第8期80-82,共3页China Pharmaceuticals

摘　　要：目的提高临床医务人员对多西环素不良反应的认识,保障患者用药安全。方法报道并分析3例注射用盐酸多西环素所致静脉炎的药品不良反应,并检索中国知网、万方数据库、维普网、Pub Med等数据库资源,收集使用注射用盐酸多西环素出现静脉炎的相关文献,对多西环素不良反应进行归纳分析。结果注射用盐酸多西环素可致静脉炎。近10年文献报道的多西环素不良反应病例中,危及生命的严重不良反应8例,其中静脉给药4例,占静脉给药不良反应的80.00%;口服给药4例,占口服给药不良反应的9.30%。结论注射用盐酸多西环素可引起静脉炎及全身性严重不良反应,静脉给药途径更易导致严重不良反应。建议能口服者尽量避免静脉用药,保证患者用药安全、有效。Objective To enhance the knowledge of the adverse reaction induced by doxycycline hydrochloride,and to protect the safety of patients. Methods To report and analyze 3 cases of phlebitis caused by doxycycline hydrochloride for injection, relevant literatures in China National Knowledge Infrastructure, Wanfang Database, VIP network and PubMed were retrieved and collected to summary and analyze its adverse reactions. Results Doxycycline hydrochloride for injection can cause phlebitis. There were 8 cases of serious adverse reactions life- threatening in the literatures of adverse reactions caused by doxycycline hydrochloride, 4 cases were induced by intra- venous administration,which accounted for 80.00% in intravenous drug adverse reactions,and 4 cases were induced by oral administra- tion, which accounted for 9.30% in oral drug adverse reactions. Conclusion Doxycycline hydrochloride for injection can cause the phlebitis and systemic serious adverse reactions, and the serious adverse reactions life- threatening is easily caused by intravenous ad- ministration. To ensure the safe and effective use of drugs,we should try to avoid intravenous administration when oral administration is allowed.

关 键 词：注射用盐酸多西环素 静脉炎 药品不良反应 合理用药 

分 类 号：R969.3[医药卫生—药理学] R978.14[医药卫生—药学]