中医病因学研究新模式下探索胃肠积热在小儿反复呼吸道感染发病中的作用  

Association between syndrome of accumulated heat in stomach and intestine and ecurrent respiratory tract infection in children under the new research model of TCM etiology

作　　者：董斐[1] 于河[1] 刘铁钢[1] 郑子安[1] 万宇翔[1] 严利依 王云辉[1] 吴力群[2] 谷晓红[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029 [2]北京中医药大学东方医院,北京100078

出　　处：《中华中医药杂志》2016年第5期1568-1571,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金面上项目(No.81373769);北京中医药大学基本科研业务费在读研究生项目(No.2015-JYB-XS009)~~

摘　　要：目的:在中医病因学研究新模式下探索胃肠积热在小儿反复呼吸道感染(RRTI)发病中的作用。方法:采用巢式病例-对照研究的方法,从前瞻性队列研究中选取研究对象,按照年龄和性别配对。选择队列研究中1-14岁的研究对象分为病例组(患有RRTI)与对照组(无RRTI),中医症状体征、人口学特征使用资料提取表收集。使用《胃肠积热诊断量表(儿科部分)》评价研究对象是否存在胃肠积热。采用条件Logistic回归的方法计算比值比(OR)与95%CI来表示胃肠积热与RRTI的相关性并筛选相关独立变量。结果:入组研究对象230例,病例组对照组=1∶1。1病例组60.00%有胃肠积热,对照组43.48%有胃肠积热(P=0.014)。OR=2.000(95%CI[1.153,3.469])。2易过敏(OR=2.544,95%CI[1.081,5.987])、口腔溃疡(OR=1.524,95%CI[1.001,2.319])、大便干(OR=1.377,95%CI[1.053,1.799])均与RRTI存在明显正相关。结论:胃肠积热与RRTI在本研究中具有正相关性,在小儿RRTI的发病中不可被忽视。Objective： To explore the association between syndrome of accumulated heat in stomach and intestine and recurrent respiratory tract infection（RRTI） in children under the new research model of TCM etiology. Methods： By the nested case-control study, participants were matched by age and gender and recruited from a prospective cohort study. Participants aged 1-14 were recruited from this cohort study and divided into case group（with RRTI） and control group（without RRTI）, Semistructured questionnaires were used to collect TCM symptoms, demographic and physiological characteristics. AccumulatedHeat in Stomach and Intestine Diagnosis Scale was used to identify whether the participants had syndrome of accumulated heat in stomach and intestine or not. Conditional Logistic regression models were used and association between dependent and independent variables was assessed by using odds ratios（OR） value and 95%CI. Results： Two hundred and thirty questionnaires were collected（case∶control=1∶1）. 160.00% of children with RRTI were diagnosed with accumulated heat in stomach and intestine, compared with 43.48% in children without RRTI（P=0.014）. The OR value of accumulated heat in stomach and intestine and RRTI is 2.000（95%CI[1.153, 3.469]）. 2Allergy history（OR=2.544, 95%CI [1.081, 5.987]）, oral ulcer（OR=1.524, 95%CI[1.001, 2.319]）, dry stool（OR=1.377, 95%CI [1.053, 1.799]） were all positively correlated with RRTI. Conclusion： Accumulated heat in stomach and intestine had a positive correlation with RRTI in this nested case-control study, which should not be ignored on children＇s RRTI.

关 键 词：胃肠积热 反复呼吸道感染 巢式病例-对照研究 小儿 中医病因学研究 

分 类 号：R272[医药卫生—中医儿科学]