清肝解郁方改善偏头痛肝郁化热证患者证候的临床研究  

Clinical research of Qinggan Jieyu Formula to improve migraine patients with the syndrome of liver depression transforming into heat

作　　者：韩芳[1] 曹克刚[1] 高颖[1] 

机构地区：[1]北京中医药大学东直门医院,北京100700

出　　处：《中华中医药杂志》2016年第5期1850-1853,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81273688);北京中医药大学创新团队项目(No.2011-CXTD-22)~~

摘　　要：目的:观察清肝解郁方对肝郁化热证偏头痛患者中医证候的影响。方法:采用随机对照的临床试验设计,将60例患者随机分为治疗组和对照组,每组30例,治疗组服用清肝解郁方免煎颗粒(200m L/次,2次/d,冲服),对照组服用天舒胶囊(4粒/次,3次/d,口服),疗程为4周,治疗结束4周后随访1次。在治疗1周、2周、3周、4周及治疗结束4周时,分别观察两组中医证候的改善情况,并观察治疗4周后两组患者头痛发作次数减半率。结果:研究期间,两组肝郁化热证证候总分基本呈下降趋势,治疗4周后及随访期证候总分组间比较,差异有统计学意义(P<0.05,P<0.01);两组不同时点证候总分与基线差值的组间比较,差异均有统计学意义(P<0.01);治疗后,两组主症积分的组间比较,第4周时差异有统计学意义(P<0.05);次症积分的组间比较,随访期差异有统计学意义(P<0.01);治疗前后两组头痛发作次数减半率组间比较,差异有统计学意义(P<0.05)。结论:清肝解郁方可明显改善肝郁化热证偏头痛患者的证候,且对偏头痛的病情改善较为明显。Objective： To observe effect of Qinggan Jieyu Formula in the treatment of migraine patients with the syndrome of liver depression transforming into heat. Methods： Designing a randomized controlled clinical trial, 60 eligible migraineurs were enrolled and assigned to 2 groups with a ratio of 1：1. The treatment group was given Qinggan Jieyu Formula granule, and the control group was given Tianshu Capsule, for a 4-week course of treatment. There was also a 4-week followup after the treatment. Then the improving situation of TCM syndrome was observed at 1 week, 2 week, 3 week, 4 week and follow-up period. We also observed the halving rate of migraine attacks after 4 weeks＇ treatment. Results： The total scores of the syndrome of liver depression transforming into heat in the two groups showed a decreasing trend. There were statistical differences in the total scores between the two groups at week 4 and follow-up period（P〈0.05, P〈0.01）. The total scores of the syndrome of liver depression transforming into heat and the baseline difference value had significant differences between the two groups at different time points（P〈0.01）. After treatment, the scores of main symptoms between the two groups had statistical difference at 4th week（P〈0.05）. The scoring of minor symptoms between the two groups had statistical difference at follow-up period（P〈0.01）. There was statistical difference in the halving rate of migraine attacks before and after treatment（P〈0.05）. Conclusion： Qinggan Jieyu Formula could apparently improve the migraine patients with syndrome of liver depression transforming into heat and had a good efficacy in the treatment of migraine.

关 键 词：清肝解郁方 偏头痛 肝郁化热证 病证结合 

分 类 号：R277.7[医药卫生—中医学]