七叶皂苷钠治疗2型糖尿病胃旁路术术后胃轻瘫的效果  

Effect of Sodium Aescinate in the treatment of gastroparesis after gastric bypass in patients with type 2 diabetes mellitus

作　　者：童艳兰 张苗[1] 周金强[1] 甄敬辉 李扬[1] 刘增亮[1] 王辉[1] 

机构地区：[1]河北省涿州市医院普外一科,河北涿州072750

出　　处：《中国医药导报》2016年第12期152-155,共4页China Medical Herald

基　　金：河北省保定市科学技术研究与发展指导计划项目(14ZF089)

摘　　要：目的观察七叶皂苷钠治疗2型糖尿病患者胃旁路术术后胃轻瘫的临床效果。方法 选取2013年6月~2015年6月在涿州市医院普外一科就诊的2型糖尿病胃旁路术术后胃轻瘫患者80例为研究对象,采用随机数字表法将其分为试验组和对照组,每组各40例。试验组给予常规糖尿病治疗加七叶皂苷钠,对照组予以常规糖尿病治疗。观察两组治疗前后胃半排空时间、临床症状改善程度和临床疗效,比较两组治疗前后血糖水平。结果1试验组治疗后临床症状评分（分）显著低于对照组[（6.07±1.70）比（10.05±1.27）]（P〈0.05）,胃半排空时间（min）显著短于对照组[（24.76±8.03）比（36.49±10.33）]（P〈0.05）。2试验组治疗后有效率（84.62%）显著高于对照组（35.00%）,差异有统计学意义（P〈0.05）。3试验组治疗后空腹血糖、餐后2 h血糖水平（mmol/L）显著低于对照组[（7.24±0.65）比（7.93±0.83）;（10.27±1.01）比（11.53±1.09）],差异均有统计学意义（P〈0.05）。结论 七叶皂苷钠治疗2型糖尿病胃旁路术术后胃轻瘫能显著缩短胃半排空时间,改善临床症状和血糖水平,提高临床疗效,值得推广应用。Objective To observe the clinical effect of Sodium Aescinate in the treatment of gastroparesis after gastric bypass in patients with type 2 diabetes mellitus. Methods Eighty cases of gastroparesis after gastric bypass patients with type 2 diabetes mellitus in Zhuozhou City Hospital from June 2013 to June 2015 were selected as research objects and they were divided into experimental group and control group by random number table method, with 40 cases in each group. Experimental group was given conventional diabetes mellitus therapy combined with Sodium Aescinate, while the control group was given conventional diabetes mellitus therapy only. The gastric emptying time before and af- ter treatment, improvement degree of clinical symptoms and clinical therapeutic effect of the two groups were observed. The levels of blood glucose before and after treatment in the two groups were compared. Results （~）After treatment, the clinical symptom score （points） of experimental group was lower than that of control group [（6.07＋1.70） vs （10.05＋1.27）] （P 〈 0.05）, the gastric half emptying time （rain） of experimental group was significantly shorter than that of control group [（24.76＋8.03） vs （36.49_＋10.33）] （P 〈 0.05）. （~）The effective rate of experimental group （84.62%） was much higher than that of control group （35.00%）, the difference was statistically significant （P 〈 0.05）. （~）The levels of fasting blood glu- cose, 2 hours postprandial blood glucose （mmol/L） of experimental group after treatment were lower than those of con- trol group [（7.24＋0.65） vs （7.93_＋0.83）; （10.27＋1.01） vs （11.53-＋1.09）], the differences were all statistically significant （P 〈 0.05）. Conclusion Sodium Aescinate in the treatment of gastroparesis after gastric bypass in patients with type 2 diabetes mellitus can significantly shorten the gastric half emptying time, improve clinical symptoms, blood glucose levels and clinical efficacy, which is worthy o

关 键 词：七叶皂苷钠 2型糖尿病 胃旁路术 胃轻瘫 

分 类 号：R587.2[医药卫生—内分泌]