糖化白蛋白对老年糖尿病患者再发脑梗死的影响  

Effect of glycated albumin on recurrent cerebral infarction in elderly patients with diabetes mellitus

作　　者：冯小萌[1] 纪蒙[2] 王广[1] 

机构地区：[1]首都医科大学附属北京朝阳医院内分泌科,100020 [2]首都医科大学附属北京朝阳医院神经内科,100020

出　　处：《中国医师进修杂志》2016年第5期440-443,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨糖化白蛋白水平对老年糖尿病患者再发脑梗死的影响。方法选择老年糖尿病合并急性脑梗死患者252例，根据糖化白蛋白水平分为A、B两组，A组糖化白蛋白〈19．0％（117例），B组糖化白蛋白≥19．0％（135例）。比较两组基本临床资料及再发脑梗死情况。结果B组糖化白蛋白、空腹血糖、总胆固醇、低密度脂蛋白胆固醇、三酰甘油水平较A组明显升高[（21．00±4．93）％比（16．75±1．72）％、（9．84±2．89）mmol／L比（5．36±1．00）mmol／L、（5．44±1．30）mmol／L比（4．57±1．00）mmol／L、（3．13±0．81）mmol／L比（2．58±0．74）mmol／L、（2．34±1．61）mmol／L比（1．74±1．47）mmol／L]，差异有统计学意义（P〈0．01或〈0．05）。B组再发脑梗死比例高于A组[53．3％（72／135）比36．8％（43／117）]，差异有统计学意义（X2=6．946，P=0．008）。Logistic回归分析显示，糖化白蛋白升高为老年糖尿病患者再发脑梗死的独立危险因素（P=0．048）。结论糖化白蛋白升高为老年糖尿病患者再发脑梗死的独立危险因素。Objective To investigate the effect of glycated albumin on recurrent cerebral infarction in elderly patients with diabetes mellitus. Methods All of 252 elderly acute cerebral infarction patients with diabetes mellitus were chosen from clinics. They were divided into 2 groups： A group （ glyeated albumin 〈 19.0% , 117 patients） and B group （ glycated albumin ≥ 19.0%, 135 patients）. The clinical characteristics and the recurrent rate of cerebral infarction were compared between two groups. Results The levels of glycated albumin, fasting blood glucose, total cholesterol, low- density lipoprotein cholesterol and triglyeerides in B group were significantly higher than those in A group： （21.00 ± 4.93）% vs. （16.75±1.72）%, （9.84 ± 2.89） mmol/L vs. （5.36 ± 1.00） mmol/L, （5.44 ± 1.30） mmol/L vs. （4.57 ± 1.00） mmol/L, （3.13±0.81） mmol/L vs. （2.58 ± 0.74） mmol/L, （2.34 ± 1.61） mmol/L vs. （1.74 ±1.47） mmol/L, P 〈 0.01 or 〈 0.05. The recurrent rate of cerebral infarction in B group was significantly higher than that in A group： 53.3% （72/135） vs.36.7% （43/117）, X2 = 6.946, P = 0.008. Logistic regression analysis showed that the increase of glyeated albumin was the independent risk factor of recurrent cerebral infarction in elderly patients with diabetes mellitus （P = 0.048）. Conclusions The recurrent rate of cerebral infarction is increased in elderly diabetes patients with high glycated albumin. The increase of glycated albumin is the independent risk factor of recurrent cerebral infarction.

关 键 词：老年人 糖尿病 脑梗塞 糖化白蛋白 

分 类 号：R587.2[医药卫生—内分泌] R743.3[医药卫生—内科学]