呋塞米联合小剂量多巴胺治疗失代偿性心力衰竭的Meta分析  

A Meta analysis on effect of furosemide combined with low-dose dopamine in treating decompensated heart failure

作　　者：王爱华[1] 廖荣宏[1] 王静[1] 

机构地区：[1]重庆医科大学附属永川医院心内科,402160

出　　处：《重庆医学》2016年第14期1934-1936,1941,共4页Chongqing medicine

摘　　要：目的采用Meta分析评价呋塞米联合小剂量多巴胺与单用呋塞米治疗失代偿性心力衰竭的疗效。方法计算机检索Cochrane Library、PubMed、OVID、Medline、Embase、中国生物医学文献数据库(CBM)、知网(CNKI)、维普(VIP)、万方等数据库,检索时间为建库至2015年1月;手工检索相关杂志纸质版。对纳入文献进行方法学质量评价,用RevMan 5.3软件进行统计分析。结果共纳入7篇随机对照试验。Meta分析结果显示与单用呋塞米组比较,联合治疗组在全因死亡率、心力衰竭再住院率、尿量、血清肌酐变化方面比较差异均无统计学意义(P>0.05),在血清钾及肾功能恶化方面,联合治疗组与单用呋塞米组差异有统计学意义(P<0.05)。结论呋塞米联合小剂量多巴胺治疗失代偿性心力衰竭的疗效并不优于单用呋塞米。Objective To systematically evaluate the efficacies of furosemide combined with low-dose dopamine and furosemide monotherapy in the treatment of decompensated heart failure.Methods The literature was retrieved in Cochrane Library,PubMed,OVID,MEDLINE,EMBASE,CBM,CNKI,VIP and Wanfang database by computer from their establishment to January 2015.The relevant magazines were retrieved manually.The quality of the included literature was assessed and Meta-analysis was performed with RevMan 5.3 software.Results Seven randomized controlled trials（RCTs）were included.The meta analysis results showed that there were no statistically significant differences in the all-cause mortality,readmission rate,heart failure,urine volume and serum creatinine change between the two groups（P〈0.05）;but in terms of worsening renal function and serum kalium change,there was statistical differences between the two groups（P〈0.05）.Conclusion The efficacy of furosemide combined with low-dose dopamine is not superior to single use of furosemide in treating decompensated heart failure.

关 键 词：呋塞米 多巴胺 失代偿性心力衰竭 Meta评价 

分 类 号：R541.6[医药卫生—心血管疾病]