索他洛尔对兔心肌电生理的影响  

Effects of Sotalol on Electrophysiology of Myocardial Cell in Rabbits

作　　者：蒋芬芬[1] 张玲玮[2] 江力勤[1] 张建勤[1] 张冉[1] 赵圣刚[1] 邓浪[1] 张祥宇[1] 

机构地区：[1]浙江省嘉兴学院附属第二医院,314000 [2]浙江省嘉兴学院附属第一医院,314000

出　　处：《心脑血管病防治》2016年第2期95-97,共3页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

基　　金：浙江省自然科学基金资助项目(编号:Y2110934);嘉兴市科技计划项目(编号:2013AY21043-6)

摘　　要：目的探讨索他洛尔口服后对兔左心室心肌细胞电生理的影响及其发生机制。方法建立冠状动脉灌注的兔左心室楔形心肌模型,应用心电图同步记录技术和浮置玻璃微电极技术,观察索他洛尔口服后兔内外两层心肌动作电位时程(action potential duration,APD)、Q-T间期及跨壁复极离散度(transmural dispersion of repolarization,TDR)的变化以及心律失常的发生。结果索他洛尔组兔内、外膜心肌细胞的APD、Q-T间期及TDR在不同刺激周长下均较对照组延长,且以内膜延长为主(均P<0.05)。索他洛尔组兔心律失常发生率较对照组升高(P<0.05)。结论索他洛尔可明显延长兔内、外膜心肌细胞的APD、Q-T间期,并可增大兔心肌细胞的TDR,在兔子模型中,应用索他洛尔容易导致心律失常发生。Objective To explore the effects and mechanism of Sotalol on electrophysiological changes of the left ventricular myocardial cells in New zealand rabbits.Methods The coronary artery perfused wedge myocardial tissue block model of the rabbit left ventricular was established first.And then we observed the changes of action potential duration （APD） of epi_and endomyocardial cells ,on Q_T in-terval and on transmural dispersion of repolarization（TDR） and arrhythmia after Sotalol being taken orally ,using recording electrocardio-gram and floating glass microelectrode.Results APD and TDR of epi_and endomyocardial cells in rabbits of Sotalol group were prolonged compared with the control group ,and there was a preferentially prolonged action potential in the endocardial cells （ P〈0.05 ）.Inci-dence of arrhythmia was also statistically significant higher than the control group （ P〈0.05）.Conclusions Sotalol can obviously pro-long the APD and the Q_T interval and also increase the TDR of the rabbits.Using Sotalol in rabbits model may lead to arrhythmia.

关 键 词：索他洛尔 动作电位时程 跨壁复极离散度 楔形心肌组织块 

分 类 号：R965[医药卫生—药理学]