急性冠状动脉综合征患者CysC、hs-CRP及Mb水平及相关性研究  

The level and correlationship of serum cystatin C,high-sensitive C-reactive protein and Myoglobin in acute coronary syndrome patients

作　　者：罗厚龙 刘行超[1] 谭秋培[1] 农妍 曾桂芬[1] 胡松林[1] 

机构地区：[1]中国人民解放军第一八一医院检验科,广西桂林541002

出　　处：《检验医学与临床》2016年第9期1156-1157,1160,共3页Laboratory Medicine and Clinic

基　　金：国家高技术研究发展计划(863计划)子课题资助项目(2011AA02A111)

摘　　要：目的探讨急性冠状动脉综合征(ACS)患者胱抑素C(CysC)、超敏C反应蛋白(hs-CRP)及肌红蛋白(Mb)之间的相关性及其临床应用价值。方法选择该院冠心病患者97例,健康对照组39例,检测血清CysC、hsCRP及Mb水平。同时检测心肌损伤标志物肌钙蛋白I(cTnI)、肌酸激酶MB亚型(CK-MB)。统计学分析采用t检验、ANOVA方差分析、Mann-Whitney U检验及Spearman相关分析。结果 ACS组CysC、hs-CRP及Mb水平显著高于健康对照组,差异有统计学意义(P<0.05)。CysC与hs-CRP及Mb呈正相关(r=0.332、0.399,P<0.05),且与病变程度呈正相关(r=0.512,P<0.05)。Mb与CK-MB、cTnI、hs-CRP及CysC呈正相关(r=0.538、0.538、0.474、0.399,P<0.05),且与病变程度呈正相关(r=0.685,P<0.05)。结论 CysC与hs-CRP呈正相关,且均与病变程度呈正相关。Mb与炎性标志物hs-CRP及CysC呈正相关,表明炎性反应和心肌损伤存在密切关系。对于ACS患者,hs-CRP与CysC与冠状动脉损伤呈正相关,Mb与心肌损伤呈正相关,其均是良好的临床预后指标。Objective To study the correlationship among cystatin C（CysC） ,high‐sensitive C‐reactive protein （hs‐CRP） and myoglobin（Mb） level of acute coronary syndrome（ACS） patients and evaluate their relationship and diagnostic values .Methods This studythat was case control study enrolled 97 coronary heart disease（CHD） patients and 39 health controls .Serum CysC ,hs‐CRP and Mb were tested .The sample was also tested myocardial injury markers such as troponin I（cTnI） ,creatin kinase MB（CK‐MB） .Student t test ,one‐way ANOVA ,Mann‐Whitney U test and Spearman test were used as statistical methods .Results The CysC ,hs‐CRP and Mb of ACS group were higher than healthy control group ,the difference were statistical significant（P〈0 .05） .After correlation with clinical date ,the CysC was positive correlated to hs‐CRP and Mb（r=0 .332 ,0 .399 ,P＆lt;0 .05） and severity of coronary artery lesion（r=0 .512 ,P〈0 .05） .Mb was positive correlated to CK‐MB ,cTnI ,hs‐CRP ,CysC（r= 0 .538 ,0 .538 ,0 .474 , 0 .399 ,P〈0 .05） and severity of coronary artery lesion（r=0 .685 ,P〈0 .05） .Conclusion CysC is positive correlated to hs‐CRP and severity of coronary artery lesion .Mb is positive correlated to inflammatory markers such as hs‐CRP and CysC .It shows that there is a close relationship between inflammation and myocardial injury .Hs‐CRP and CysC are positive correlated to coronary artery lesions ,and M b is positive correlated to myocardial injury ,they are all good prognostic indices for acute coronary syndrome patients .

关 键 词：急性冠状动脉综合征 超敏C反应蛋白 肌红蛋白 

分 类 号：R543.3[医药卫生—心血管疾病]