去乙酰毛花苷联合米力农治疗慢性气道疾病合并重症右心衰竭的效果  

Clinical observation of treatment with Deslanoside combination with Milrinone in patients with severe right ventricular failure associated with chronic airway disease

作　　者：陈锋[1] 唐家璇[1] 张磊[1] 韩雪峰[1] 乜庆荣[1] 

机构地区：[1]首都医科大学良乡教学医院呼吸内科,北京102401

出　　处：《中国当代医药》2016年第11期134-136,共3页China Modern Medicine

摘　　要：目的观察去乙酰毛花苷联合米力农治疗慢性气道疾病合并重症右心衰竭的效果。方法将2012年1月~2015年12月我院收治的68例慢性气道疾病合并重症右心衰竭患者分为治疗组（n=32）及对照组（n=36）。在常规治疗基础上,治疗组给予去乙酰毛花苷静脉注射联合米力农持续泵入,对照组给予米力农持续泵入,观察两组治疗后3、7 d的血气分析指标,24 h尿量,N末端前脑钠肽（NT-pro-BNP）,肺动脉压力（PAP）等,以及14 d的治疗有效率。结果治疗组的p H值在治疗前,治疗3、7 d后分别为7.23±0.05、7.28±0.04、7.28±0.04,改善明显（P〈0.05）,动脉氧分压（Pa O2）分别为（50.50±6.76）、（55.40±7.14）、（59.20±6.76）mm Hg,升高明显（P〈0.05）,NT-pro-BNP在治疗7 d后较治疗前明显下降[（1967.6±561.4）pg/ml vs（3757.0±1498.5）pg/ml,P〈0.05],PAP在治疗7 d后较治疗前明显降低[（45.95±7.24）mm Hg vs（56.70±6.08）mm Hg,P〈0.05],24 h尿量分别为（1414.5±227.6）、（2561.6±607.8）、（2065.0±297.4）ml,增多明显,P〈0.05],且上述指标较对照组改善程度更为明显（P〈0.05）;14 d后治疗组的治疗有效率为90.6%,明显高于对照组的69.4%（P=0.000）。结论去乙酰毛花苷和米力农联合应用可有效治疗慢性气道疾病合并重症右心衰竭。Objective To explore the clinical efficiency of Deslanoside in combination with Milrinone in treating patients with severe right ventricular failure associated with chronic airway disease. Methods 68 patients with severe right ventricular failure associated with chronic airway disease admitted in our hospital from January 2012 to December2015 were randomly divided into treatment group（n=32） and control group（n=36）.The treatment group was treated with Deslanoside in combination with Milrinone and just Milrinone for the control group on basis of conventional therapy.The arterial blood gas analysis,daily urine volume, NT-pro-BNP,pulmonary artery pressure were analyzed after being treated for 3 days and 7days,meanwhile,the clinical efficiency after being treated for 14 days were compared between the two groups. Results In treatment group, after being treated for 3 days and 7 days,the arterial blood p H was 7.23 ±0.05,7.28±0.04,7.28±0.04,respectively,with greatly improvement（P〈0.05）,the Pa O2was（50.50±6.76）,（55.40±7.14）,（59.20±6.76） mm Hg,respectively,with greatly increasing（P〈0.05）,while the NT-pro-BNP and pulmonary artery pressure was obviously decreased after being treated for 7 days [NT-pro-BNP：（1967.6±561.4） pg/ml vs（3757.0±1498.5） pg/ml,P〈0.05;PAP：（45.95±7.24） mm Hg vs（56.70±6.08） mm Hg,P〈0.05],the daily urine volume was（1414.5±227.6）,（2561.6±607.8）,（2065.0 ±297.4） ml,respectively, with obviously increasing（P 0.05）,and all parameters showed a better improvement compared with the control group（P〈0.05）.The total effective rate in the treatment group was obviously higher than in the control group（90.6% vs 69.4%,P=0.000）. Conclusion The treatment of Deslanoside in combination with Milrinone is effective for patients with severe right ventricular failure associated with chronic airway disease.

关 键 词：去乙酰毛花苷 米力农 慢性气道疾病 右心衰竭 

分 类 号：R725.4[医药卫生—儿科]