参菊洗剂体外抗阴道毛滴虫作用  

Effect of Shenju Lotion Agaisnt Trichomonas in Vagina In Vitro

作　　者：张广求[1] 

机构地区：[1]湖北省黄冈市中心医院药剂科,黄冈438000

出　　处：《医药导报》2016年第5期458-460,共3页Herald of Medicine

基　　金：湖北省黄冈市科技计划项目(黄科字[2013]76号)

摘　　要：目的探讨参菊洗剂的体外抗阴道毛滴虫作用,为临床应用提供参考。方法用肝浸液将参菊洗剂配制成400.00,200.00,100.00,50.00,25.00,12.50,6.25 mg·m L-1培养液,对阴道毛滴虫进行体外培养,分别在2,4,6,8,12,24 h观察阴道毛滴虫的形态和活动状况,计算虫体死亡率,并与相同浓度洁尔阴洗液的体外抗阴道毛滴虫效果进行比较。结果参菊洗剂在体外对临床分离的阴道毛滴虫有抑制和杀灭作用,最低有效浓度为50 mg·m L-1。参菊洗剂各浓度组阴道毛滴虫的死亡率与相同浓度的洁尔阴洗液组比较,差异无统计学意义(P>0.05)。结论参菊洗剂有明显的抗阴道毛滴虫作用。Objective To investigate the in vitro effect of ShenJu lotion agaisnt Trichomonas vaginalis in order to provide clues for its clinical application. Methods ShenJu lotion was formulated into different concentrations（400.00,200. 00,100.00,50.00,25.00,12.50,6.25 mg·mL^-1 ）with liver extracts.The morphology and movement of Trichomonas vaginalis treated with different concentrations of ShenJu lotion in vitro for 2,4,6,8,12,or 24 h were observed and the mortality was calculated.The effects against Trichomonas vaginalis were compared between Jieeryin lotion and ShenJu lotion at the same concentrations. Results ShenJu lotion could significantly inhibit and kill clinical isolates of Trichomonas vaginalis in vitro and the lowest effective concentration was 50.00 mg·mL^-1 .There was no significant difference in the mortality between ShenJu lotion and Jieeryin lotion（P＆gt;0.05）. Conclusion ShenJu lotion has obvious effects against Trichomonas vaginalis.

关 键 词：参菊洗剂 毛滴虫 阴道 实验 体外 

分 类 号：R286[医药卫生—中药学] R285.5[医药卫生—中医学]