混合糖电解质注射液与常用维生素电解质配伍的稳定性  

Compatible Stability of Carbohydrate-Electrolyte Injection and Commonly Used VitaminElectrolyte Injections

作　　者：徐兰[1] 陈集志[1] 陶晓璇[1] 封传华[1] 李刚[1] 张静[1] 

机构地区：[1]解放军第九四医院药学科,南昌330002

出　　处：《医药导报》2016年第5期526-529,共4页Herald of Medicine

摘　　要：目的考察混合糖电解质注射液与临床常用维生素、电解质注射液配伍的稳定性。方法模拟临床用药方法,分别配制混合糖电解质注射液与各类药物的配伍溶液,采用高效液相色谱(HPLC)法测定配伍后混合糖电解质注射液中醋酸钠的含量变化情况,同时考察配伍溶液的外观、p H值和不溶性微粒的变化。结果室温状态下8 h内,各配伍溶液的外观、p H值、不溶性微粒数和醋酸钠的含量均无明显变化。结论混合糖电解质注射液与临床常用维生素、电解质注射液在室温条件下8 h内稳定。Objective To study the compatible stability of the carbohydrate-electrolyte injection and commonly used vitamin-electrolyte injections. Methods By simulating clinical use of medicines,the carbohydrate-electrolyte injection and various vitamin-electrolyte injections were mixed respectively.The content of sodium acetate was measured by HPLC,and changes in appearance,pH value and insoluble particles of the injections were observed. Results At room temperature,the compatibility solutions showed no significant changes in appearance,pH value,the number of insoluble particles and the content of sodium acetate within 8 h. Conclusion The carbohydrate-electrolyte injection is compatible with commonly used vitamin-electrolyte injections,and the admixtures are stable within 8 h at room temperature.

关 键 词：混合糖电解质注射液 醋酸钠 色谱法 高效液相 稳定性 配伍 

分 类 号：R977.7[医药卫生—药品] R969.3[医药卫生—药学]