早期应用美洲大蠊提取物对感染后危重症患者胃肠功能的影响  

Early using periplaneta americana extract on gastrointestinal function in critically patients with infection

作　　者：张宏伟[1] 魏立友[2] 赵刚[1] 刘淑正[1] 杨雅静[3] 张振宇[4] 张静[4] 

机构地区：[1]唐山市第二医院华北理工大学附属唐山市第二医院重症医学科,河北省唐山063000 [2]唐山市第二医院华北理工大学附属唐山市第二医院骨科,河北省唐山063000 [3]唐山市第二医院华北理工大学附属唐山市第二医院检验科,河北省唐山063000 [4]唐山市人民医院重症医学科,河北省唐山063001

出　　处：《中国基层医药》2016年第10期1456-1459,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：河北省唐山市科学技术研究与发展指导计划项目（15130219a）

摘　　要：目的：探讨早期应用美洲大蠊提取物干预对感染后危重症患者胃肠功能的影响，并探讨其可能的机制。方法选择 ICU 的住院感染后危重症患者66例，采用随机数字表法，将患者分为对照组和治疗组各33例，对照组给予常规综合治疗，治疗组在对照组基础上给予美洲大蠊提取物治疗。分别于治疗前、治疗后3、7 d，记录患者胃肠功能评分、肠鸣音计数、APACHEⅡ评分、血乳酸浓度。结果治疗前两组胃肠功能评分、肠鸣音计数、APACHEⅡ评分、血乳酸浓度，差异均无统计学意义（t ＝0．132、0．201、0．329、0．190，均 P ＞0.05）。治疗后3、7 d，两组胃肠功能评分[（1．56±0．49）分比（1．32±0．45）分，（1．27±0．44）分比（1．02±0.42）分]；肠鸣音计数[（1．58±0．76）次／min 比（2．27±0．75）次／min，（2．15±0．91）次／min 比（3．11±0．97）次／min]；APACHEⅡ评分[（19．61±4．02）分比（17．50±4．37）分，（17．69±3．94）分比（15．24±3．82）分]；血乳酸浓度[（2．94±0．88）mmol／L 比（2．45±0．75）mmol／L，（2．51±0．59）mmol／L 比（2．20±0.55）mmol／L]，治疗组改善好于对照组，差异均有统计学意义（t3＝2．072、t7＝2．361；t3＝3．712、t7＝4．146；t3＝2．041、t7＝2．565；t3＝2．434、t7＝2．208，均 P ＜0．05）。结论早期应用美洲大蠊提取物可对感染后危重症患者的胃肠功能进行保护，并可在一定程度上改善患者病情。Objective To investigate the effect of early using periplaneta americana extract on gastrointesti-nal function in critically patients with infection,and to evaluate its possible mechanism.Methods 66 patients with infection in Intensive Care Unit（ICU）were divided into control group and treatment group（33 cases in each group） according to the random number table.All patients in the two groups were given conventional cluster treatment,the patients in the treatment group additionally received periplaneta americana extract.At the beginning of treatment and 3,7 and 10 days after treatment,the indicators of bowel sounds,gastrointestinal function,APACHEⅡ and blood lactic acid level were respectively tested or recorded.Results At the beginning of treatment,there were no statistically sig-nificant differences between the two groups in terms of gastrointestinal function,bowel sounds,APACHE II score and blood lactic acid level（t =0.132,0.201,0.329,0.190,all P 〉0.05）.3,7 days after treatment,the gastrointestinal function[（1.56 ±0.49）points vs.（1.32 ±0.45）points,（1.27 ±0.44）points vs.（1.02 ±0.42）points],bowel sounds[（1.58 ±0.76）times/min vs.（2.27 ±0.75）times/min,（2.15 ±0.91）times/min vs.（3.11 ±0.97）times/min],APACHE II score[（19.61 ±4.02）points vs.（17.50 ±4.37）points,（17.69 ±3.94）points vs.（15.24 ± 3.82）points]and blood lactic acid level[（2.94 ±0.88）mmol/L vs.（2.45 ±0.75）mmol/L,（2.51 ±0.59）mmol/L vs.（2.20 ±0.55）mmol/L],the terms in the treatment were better than those in the control group,the differences were statistically significant（t3 =2.072,t7 =2.361;t3 =3.712,t7 =4.146;t3 =2.041,t7 =2.565;t3 =2.434,t7 =2.208,all P 〈0.05）.Conclusion Early using periplaneta americana extract has protective effect on gastrointestinal function in critically patients with infection,and improve the condition in a certain degree.

关 键 词：大蠊属 组织提取物 感染 胃肠活动 

分 类 号：R459.7[医药卫生—急诊医学]