斑马鱼在发育毒理学研究中的应用  

Application of zebrafish to developmental toxicology research

作　　者：李盛[1] 龙鼎新[1] 

机构地区：[1]南华大学公共卫生学院,湖南衡阳421001

出　　处：《实用预防医学》2016年第6期762-765,共4页Practical Preventive Medicine

基　　金：国家自然科学基金(81172712);南华大学博士启动基金(2010XQD19)

摘　　要：斑马鱼作为一种标准模式脊椎动物以其独特的优势被广泛应用于发育毒理学研究,目前研究工作涉及到几乎斑马鱼所有器官系统的发育过程及在毒理学中的应用。本文从心脏发育毒性、血管和血细胞发育毒性、神经发育毒性、肝脏及肾脏发育毒性、体节、肌肉和骨骼发育毒性等方面综述了斑马鱼应用研究进展。As a standard vertebrate animal model, zebrafish is widely applied to developmental toxicology study with its unique advantages. At present, the research work involves the developmental process of almost all the organs and systems of zebrafish and its application in toxicology. This paper reviews the research progress on the application of zebrafish to developmental toxicology, such as cardiac developmental toxicity, vascular and blood cell developmental toxicity, neuronal developmental toxicity, liver and kidney developmental toxicity, somite, muscular and skeletal developmental toxicity.

关 键 词：斑马鱼 胚胎 发育毒理学 

分 类 号：R114[医药卫生—卫生毒理学]