体质量超标准和肥胖与痛风发病风险关系Meta分析  

THE ASSOCIATION OF OVERWEIGHT AND OBESITY WITH GOUT:A META ANALYSIS

作　　者：杨丽[1] 姜文洁[1] 张东峰[1] 

机构地区：[1]青岛大学医学院流行病与卫生统计学教研室,山东青岛266021

出　　处：《齐鲁医学杂志》2016年第2期203-206,共4页Medical Journal of Qilu

摘　　要：目的探讨体质量超标准（超标）和肥胖与痛风发病风险之间的关系。方法检索PubMed、Web of Science、万方、维普以及中国知网数据库,收集从建库至2015年9月所有有关超标和肥胖与痛风发病风险关系的中英文文献。采用随机效应模型来计算合并相对危险度（RR）以及95%可信区间（CI）。结果共有9篇文献包含249 739例研究对象符合超标的纳入标准,11篇文献包含382 548例研究对象符合Ⅰ级肥胖的纳入标准,3篇文献包含68 946例研究对象符合Ⅱ或Ⅲ级肥胖的纳入标准。超标、Ⅰ级肥胖和Ⅱ或Ⅲ级肥胖的合并RR分别为1.52（95%CI=1.35~1.72）、2.12（95%CI=1.81~2.48）和2.60（95%CI=1.93~3.50）。结论超标和肥胖与痛风的发病风险增加有关。Objective To assess the correlation of overweight and obesity with the risk of gout. Methods Literatures concerning association of overweight and obesity with the risk of gout-- published in Chinese or English-- were retrieved from PubMed, Web of Science, Wanfang, Weipu and CNKI database, from the establishment of the database to September 2015. Ap- plying random effect model, pooled RR and 95% CI were calculated. Results Nine articles including 249 739 objects of study met the inclusion criteria for overweight, 11 articles with 382 548 objects of study for obesity class, and three articles with 68 946 objects of study met the standard for obesity class Ⅱ or Ⅲ. The pooled RRs with 95% CIs of gout for overweight, obesity class I and obesity class Ⅱ or Ⅲ were 1.52 （95%CI=1.35-1.72）, 2.12 （95%C1=1.81-2.48） and 2.60 （95%CI=1.93--3.50）, re- spectively. Conclusion Overweight and obesity are related with the increased risk of gout.

关 键 词：超重 肥胖症 痛风 META分析 

分 类 号：R589.7[医药卫生—内分泌] R589.25[医药卫生—内科学]