硫辛酸联合精蛋白生物合成人胰岛素注射液治疗2型糖尿病的疗效观察  

Clinical observation of thioctic acid combined with Isophane Protamine Biosynthetic Human Insulin Injection in treatment of type 2 diabetes

作　　者：胡开宇[1] 程晓芸[2] 汤春红[1] 

机构地区：[1]上海市闵行区龙柏社区卫生服务中心,上海201105 [2]上海市第十人民医院,上海200072

出　　处：《现代药物与临床》2016年第4期463-466,共4页Drugs & Clinic

摘　　要：目的研究硫辛酸联合精蛋白生物合成人胰岛素注射液治疗2型糖尿病的临床疗效。方法选取2012年8月—2015年12月上海市闵行区龙柏社区卫生服务中心收治的2型糖尿病患者300例,随机分为对照组和治疗组,每组各150例。对照组患者皮下注射精蛋白生物合成人胰岛素注射液,初次为0.4 U/kg,2次/d分别是每日早晚餐前,以后根据患者的治疗状况确定注射剂量的增减。治疗组在对照组的基础上静脉注射硫辛酸注射液,0.6 g加入生理盐水250 m L,1次/d。两组均连续治疗1个月。观察两组胰岛素用量情况,比较治疗前后两组空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(Hb A1c)、生活质量评分的变化。结果治疗组的胰岛素注射剂量在早、晚餐前,全天用量均显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者FBG、2 h PBG、Hb A1c均较治疗前显著降低,同组治疗前后差异具有统计学意义(P<0.05);治疗后治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者承受压力评分、社会关系评分、营养状况评分、运动状况评分均较治疗前显著增加,同组治疗前后差异具有统计学意义(P<0.05);治疗后治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论硫辛酸联合精蛋白生物合成人胰岛素注射液治疗2型糖尿病具有较好的临床疗效,可减少患者注射胰岛素的剂量,能够更好地控制空腹血糖和餐后2 h血糖,提高患者的生活质量,具有一定的临床推广应用价值。Objective To investigate the clinical effect of thioctic acid combined with Isophane Protamine Biosynthetic Human Insulin Injection in treatment of type 2 diabetes. Methods Patients （300 cases） with type 2 diabetes in Longbai Community Health Service Center of Minhang District in Shanghai from August 2012 to December 2015 were randomly divided into control and treatment groups, and each group had 150 cases. The patients in the control group were sc administered with Isophane Protamine Biosynthetic Human Insulin Injection, 0.4 U/kg for the first time, twice daily, before breakfast and dinner. The dosage was adjusted according to the treatment status of patients. The patients in two groups were treated for 1 month. The dosages of insulin in two groups were observed, and the changes of FBG, 2 h PBG, HbA1c, and scores of quality life in two groups before and after treatment were compared. Results After treatment, the dosage of insulin in treatment group before breakfast, dinner and throughout the day were significantly lower than those in the control group, and there were differences between two groups （P 〈 0.05）. After treatment, FBG, 2 h PBG, and HbA1c in two groups were significantly decreased, and the difference was statistically significant in the same group （P 〈 0.05）. After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups （P 〈 0.05）. After treatment, the scores of stress evaluation, social relations, nutritional status, and exercising state were significantly increased, and the difference was statistically significant in the same group （P 〈0.05）. After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups （P 〈 0.05）. Conclusion Thioctic acid combined with Isophane Protamine Biosynthetic Human Insulin Injection has clinical curative effect in treatment

关 键 词：硫辛酸注射液 精蛋白生物合成人胰岛素注射液 2型糖尿病 空腹血糖 餐后2H血糖 糖化血红蛋白 

分 类 号：R977[医药卫生—药品]