丁苯酞联合依达拉奉对急性一氧化碳中毒迟发性脑病患者精神状态与认知功能的影响  

Effects of combination of Butylphthalide and edaravone on mental status and cognitive function in delayded encepha-lopathy after acute carbon monoxide poisoning patients

作　　者：方建飞[1] 王芳[2] 徐杰[1] 李伟[1] 陆岩[1] 

机构地区：[1]河北省唐山市开滦总医院急诊科,河北唐山063000 [2]河北省唐山市协和医院神经内科,河北唐山063000

出　　处：《河北医科大学学报》2016年第5期501-505,共5页Journal of Hebei Medical University

摘　　要：目的探讨丁苯酞联合依达拉奉对急性一氧化碳中毒迟发性脑病（delayded encepha-lopathy after acute carbon monoxide poisoning,DEACMP）患者精神状态与认知功能的影响。方法选取100例DEACMP患者,按随机数字表法分为对照组和观察组各50例。对照组采取常规治疗,观察组在常规治疗的基础上联合丁苯酞、依达拉奉治疗,2组均治疗3个疗程,疗程结束时评价疗效。治疗前和治疗1、2、3个疗程评定简易智能精神量表（mini-mental state examination,MMSE）,治疗前和疗程结束时评定美国国立卫生研究院卒中量表（National Institutes of Health Stroke Scale,NIHSS）、Barthel指数（Barthel index,BI）、长谷川痴呆量表（Hastgawa Dementia Scale,HDS）。结果观察组总有效率明显高于对照组（χ^2=5.741,P〈0.05）;治疗后2组MMSE评分均较治疗前明显升高,随着疗程的进展,MMSE评分不断增加,且观察组各时点MMSE评分高于对照组,组间、时点间、组间·时点间交互作用差异均有统计学意义（P〈0.05）。2组NIHSS评分较治疗前明显降低,BI、HDS评分均较治疗前明显升高（P〈0.05）;观察组NIHSS评分低于对照组,BI、HDS评分高于对照组（P〈0.05）。结论丁苯酞联合依达拉奉治疗DEACMP安全、有效,可明显改善患者的精神状态及认知功能障碍,提高患者的日常生活能力及智力水平,值得在临床上推广应用。Objective To investigate the effects of combination of Butylphthalide and edaravone on mental status and cognitive function in delayed encephalopathy after actue carbon monoxide poisoning（DEACMP）patients.Methods A total of 100 cases DEACMP patients were randomly divided into control group and observation group,with 50 cases in each group.The control group of patients were applied conventional treatment,the observation group were treated with Butylphthalide and edaravone on the basis of conventional treatment.The efficiency of two groups were observed after 3treatment courses.Before treatment and in treatment course 1,2,3,the patients were evaluated with simple-mental assessment scale（mini-mental state examination,MMSE）.Before and after treatment,the efficiency was evaluated with National Institutes of Health Stroke Scale（NIHSS）,Barthel index（BI）and Hasegawa Dementia Scale（HDS）.Results The clinical effect of observation group was significantly better than that of control group（χ^2=5.741,P〈0.05）;MMSE score in control group and in observation group after treatment were higher than those in groups before treatment.With the progress of treatment,MMSE score was increased.The MMSE score in observation group was higher than those in control group at each time point.The difference was statistically significant between groups and different time,also at different time points interaction（P〈0.05）.The NIHSS score of the observation group was lower than those in control group at each time point.The NIHSS score was significantly lower than those in groups before treatment,BI scores and HDS scores was significantly increased before treatment.NIHSS score in observation group was lower than those in the control group,BI score and HDS scores were higher than those in the control group（P〈0.05）.Conclusion Application of Butylphthalide and edaravone in the treatment of delayed encephalopathy after acute carbon monoxide poisoning can significantly improve mental state and cognitive dysfunction,also

关 键 词：一氧化碳中毒 脑疾病 丁苯酞 依达拉奉 

分 类 号：R595.1[医药卫生—内科学]