有氧运动对不稳定性心绞痛患者的胰高血糖素样肽-1、血脂和心功能指标的影响  

Effects of aerobic exercise on glucagon-like peptide-1, blood lipids and cardiac function indexes in patients with unstable angina

作　　者：王鹏[1] 刘玉洁[1] 周秀军[1] 张颖[1] 王明辉[1] 

机构地区：[1]天津市胸科医院心血管内科,天津300222

出　　处：《中国慢性病预防与控制》2016年第5期340-342,347,共4页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：天津市卫生局自筹项目(2012KZ056)

摘　　要：目的研究有氧运动对不稳定性心绞痛患者的胰高血糖素样肽-1（GLP-1）等因子的影响,为有针对性地建议不稳定性心绞痛患者进行有氧运动提供依据。方法选取2014年1-12月天津市胸科医院心内科160例已确诊为不稳定性心绞痛的患者为研究对象,男性81例,女性79例,年龄60~80岁,平均（61.2±1.2）岁,随机分为运动组（80例）和对照组（80例）,运动组接受单硝酸异山梨酯片（欣康20 mg,3次/d）或单硝酸异山梨酯缓释片（索尼特60 mg,1次/d）、琥珀酸美托洛尔缓释片（倍他乐克23.75~47.50 mg,1次/d）和阿托伐他汀钙（立普妥20~40 mg,每晚1次）或瑞舒伐他汀钙（可定5~10 mg每晚1次）,并附加有氧运动,对照组仅接受西医治疗不附加有氧运动,比较两组患者治疗前后生化指标的变化。采用SPSS 17.0软件进行χ2检验、配对样本t检验、独立样本t检验或秩和检验。结果治疗前,运动组与对照组患者的GLP-1、半胱氨酸（Hcy）、血清超敏C反应蛋白（hs-CRP）水平等的差异均无统计学意义（P〉0.05）。经过6个月治疗后,运动组治疗后血糖、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、Hcy和hs-CRP水平均明显低于本组治疗前和对照组治疗后,差异均有统计学意义（P〈0.05）。对照组治疗后TG、LDL-C、Hcy和hs-CRP水平均明显低于本组治疗前,差异均有统计学意义（P〈0.05）。运动组患者治疗后的GLP-1水平[（34.71±1.32）pmol/L]明显高于本组治疗前[（28.58±1.01）pmol/L]和对照组治疗后[（30.94±1.77）pmol/L],差异均有统计学意义（P〈0.05）。对照组治疗后GLP-1水平明显高于本组治疗前[（29.11±1.59）pmol/L],差异有统计学意义（P〈0.05）。心电图结果显示,运动组显效和有效人数（分别为35、40例）明显高于对照组（分别为20、32例）,差异有统计学意义（P〈0.01）。结论有氧运动能够降低不稳定性心�Objective To study the effects of aerobic exercise on glucagon-like peptide-1 （GLP-1） and other factors in patients with unstable angina and to provide the basis for performing the aerobic exercise in patients with unstable angina. Methods A total of 160 cases （81 males and 79 females; 60-80 years old, mean 61.2±1.2 years old） of hospitalized and diagnosed as unstable angina patients were selected as the subjects. The subjects were randomly divided into exercise group （80 cases） and control group （80 cases）. The exercise group treated with syncon （20 rag, rid） or sonett （60 rag, 1 time/day ） or metoprolol （23.75-47.50 rag, 1 time/day ） or lipitor （20-40 rmg, 1 time/day ） or orestor （5-10 mg, 1 time/day ） performed the aerobic exercise. But the control group was only treated with western medications without the aerobic exercise. The changes of biochemical indexes before and after treatment for 6 months were compared between two groups. SPSS 17.0 software was used to analyze all data using x^2 test, t Test and rank-sum test. Results Before treatment, there were no differences of glucagon-like peptide-1 （GLP-1）, homocysteine （Hey）, serum hypersensitive C-reactive protein （hs-CRP） and other parameters between two groups （P〉0.05）. After treatment for 6 months, the levels of blood glucose, TC, TG, LDL-C, Hey and hs-CRP of the exercise group were significantly lower than the levels before treatment and the levels of control group （P〈0.05）; and the levels of TG, LDL-C, Hey and hs-CRP of control group were signifieantly lower than the levels before treatment （P〈0.05）; the level （34.71±1.32 pmol/L） of GLP-1 of exercise group was significantly higher than the level （28.58±1.01 pmol/L） before treatment and the level （30.94±1.77 pmol/L） of control group （P〈 0.05 ）; the level （30.94± 1.77 pmol/L） of GLP-1 of the control group was significantly higher than the level （29.11 ±1.59 pmol/L） before treatment （P〈0.05）. The ECG resu

关 键 词：不稳定性心绞痛 胰高血糖素样肽-1 有氧运动 血脂 

分 类 号：R181.3[医药卫生—流行病学]