中性粒细胞淋巴细胞比值与原发性高血压左心室肥厚的相关性分析  

Relationship between neutrophil/lymphocyte ratio and left ventricular hypertrophy in patients with essential hypertension

作　　者：刘建峰 武艺[2] 郝鹏[3] 罗鸿宇[4] 华琦[4] 

机构地区：[1]北京市利康医院住院部,北京市102609 [2]首都医科大学康复医学院中国康复研究中心北京博爱医院心内科 [3]首都医科大学附属北京安贞医院急诊科 [4]首都医科大学宣武医院心脏科

出　　处：《中国心血管病研究》2016年第4期326-330,共5页Chinese Journal of Cardiovascular Research

基　　金：国家高科技发展计划（863计划）（项目编号：2012AA02A516）

摘　　要：目的探讨中性粒细胞和淋巴细胞比值（NLR）与原发性高血压患者左心室肥厚（LVH）之间的关系。方法入选宣武医院心脏科门诊新发未经治疗的原发性高血压患者480例作为研究对象。所有患者均行超声心动图检查并计算左室心肌质量指数（LVMI）。定义LVH为：女性患者LVMI≥110g／m2，男性患者LVMI≥135g／m2。根据LVMI将入选者分为高血压合并左心室肥厚组（LVH组，n=198）和高血压无左心室肥厚组（non—LVH组，n=282）。同时均检测生化指标及血常规指标。应用SPSS软件分析NLR与高血压患者LVH的相关性。结果①与高血压无LVH组比较，高血压合并LVH组NLR水平明显升高，差异有统计学意义（P〈0．05）。②相关性分析显示，NLR水平与LVMI呈正性相关（r=0．411，P〈0．05）。③Logistic回归分析显示，在校正了收缩压、空腹血糖、血尿酸及血肌酐等因素后，NLR仍是高血压合并左心室肥厚的独立危险因素（OR=2．350，95％CI1．720±3．210，P〈0．05）。结论高血压伴左心室肥厚患者NLR与无左心室肥厚的高血压患者比较明显升高。NLR升高可能是原发性高血压患者并发左心室肥厚的独立危险因素。Objective To investigate the relationship between the neutrophil/lymphocyte ratio （NLR） and left ventricular hypertrophy in untreated essential hypertensive patients. Methods A total of 480 patients with es- sential hypertension were chosen from cardiac outpatients of Xuanwu Hospital. The biochemical indexes, blood rou- tine index and echocardiography were detected, the left ventricular myocardial mass index （LVMI） was calculated. Definition of left ventricular hypertrophy： women with LVMI ≥ 110 g/m2 or men with LVMI ≥ 135 g/m2. All patients were divided into 2 groups according to the LVMI： LVH group（n= 198） and non-LVH group（n=282）. The corre- lation between NLR and LVH of hypertension patients was analyzed. Results The level of NLR increased in LVH group compared with non-LVH group[ （2.51±0.69） vs （2.00±0.68）, P〈0.05 ]. Pearson correlation analysis showed that NLR was positively correlated with LVMI （r=0.411, P〈0.05 ）. Logistic analysis showed that NLR was the im- portant independent risk factor for LVH in essential hypertension patients after adjusted for Systolic blood pressure （SBP）, uric acid （UA）, fasting plasma glucose （FBG）, serum creatinine （SCr）（OR=2.350, 95%CI 11.720- 3.210, P〈0.05 ）. Conclusion The level of NLR will increase in hypertension combined with LVH compared with non-LVH group. NLR may be an independent risk factor of hypertension combined with LVH.

关 键 词：中性粒细胞与淋巴细胞比值 原发性高血压 左心室肥厚 左室心肌质量指数 

分 类 号：R544.1[医药卫生—心血管疾病]