ABCA1表达的microRNA转录后水平调控  

The Regulation of ABCA1 Expression by MicroRNA on Post-transcription

作　　者：唐蕙[1] 刘益洲 肖文超[2] 马小峰[2] 王佐[1] 姜志胜[1] 

机构地区：[1]南华大学心血管疾病研究所 [2]南华大学附属南华医院,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2016年第5期517-523,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81070221)

摘　　要：胆固醇逆转运(RCT)是体内清除胆固醇的重要机制,对维持体内胆固醇稳态,预防动脉粥样硬化有着重要意义。ATP结合盒转运体A1(ABCA1)是胆固醇逆转运过程中的关键因子,ABCA1的表达受到转录水平和转录后水平的多种因素调控,其中microRNA介导ABCA1表达的转录后水平调控备受重视。近年来的研究发现,多种microRNA能直接以ABCA1为靶基因调控ABCA1的表达,同时也发现一些microRNA通过作用于调控ABCA1基因的转录因子间接发挥效应,如肝X受体α(LXRα)、过氧化体增殖物激活型受体γ(PPARγ)、视黄醇类核内受体α(RXRα)等间接调控ABCA1的表达,从而达到影响胆固醇流出的目的。这些microRNA包括miR-33a/b、miR-19b、miR-27a/b、miR-302、miR-758及miR-106b等。本文主要综述已知microRNA对ABCA1表达的影响。Reverse cholesterol transport（ RCT） is an important mechanism to remove cholesterol,and it has important significance to maintain cholesterol homeostasis and prevent atherosclerosis. ATP-binding cassette transporter A1（ ABCA1） is the key factor of RCT,the expression of ABCA1 is controlled by many factors of transcriptional level and posttranscriptional level. The post-transcriptional level of the expression of ABCA1 mediated by microRNA,is attached importance. According to the recent researches,kinds of microRNAs have regulated the ABCA1 expression directly by treating the ABCA1 as target gene,at the same time,they also have found some microRNAs take effects indirectly by regulating the transcription factor of the ABCA1 gene. For example,liver X receptor α（ LXRα）,peroxisome proliferator activated receptor γ（ PPARγ）,retinoid X receptor α（ RXRα） are regulating ABCA1 expression,so as to affect cholesterol efflux,these microRNAs include miR-33 a / b,miR-19 b,miR-27 a / b,miR-302,miR-758,miR-106 b and so on. This article mainly reviews various known microRNAs influence on ABCA1 expression.

关 键 词：ATP结合盒转运体A1 MICRORNA 胆固醇逆转运 肝X受体Α 过氧化体增殖物激活型受体Γ 

分 类 号：Q81[生物学—生物工程]