中药治疗寒性哮喘的Meta分析  

A Meta-analysis: Traditional Chinese Medicine on Cold Type Asthma

作　　者：刘璐佳 曲婉莹 谭杰军[1] 施国善 景伟超 张鑫[1] 王有鹏[2] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150001

出　　处：《中国中医急症》2016年第5期777-781,815,共6页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81473724)

摘　　要：目的评价中药治疗寒性哮喘的疗效和安全性。方法计算机检索Pub Med、CBM、CNKI、VIP和Wan Fang Data等数据库,1995年1月1日至2015年10月31日中药治疗寒性哮喘的随机对照研究文献。由2位研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用Rev Man5.3软件进行Meta分析。结果共纳入27篇文献,包含2475例患者。此次Meta分析结果显示,观察组中药治疗寒性哮喘的总有效率高于西药对照组,且中药在改善患者肺功能(FEV1、FEV1%、PEF%、FVC、PEFR)指标,及治疗主症(喘息、胸闷、咳痰、哮鸣音)症状方面均优于西药治疗,在改善PEF方面治疗组与对照组作用相当。本研究纳入的文献中大部分研究未对服用中药后的不良反应进行报告,因此,临床口服中药治疗寒性哮喘的安全性目前尚不能做出肯定结论。结论基于当前临床证据显示,中药在治疗寒性哮喘上有较好的临床效果,但由于现有试验的方法学质量普遍较低,要得到更加可靠的结论,今后仍需要大样本、多中心以及合理运用盲法的高质量临床研究,以提供具有更高可靠性、准确性的评价结果。Objective： To evaluate effectiveness and safety of Chinese medicine treatment for cold type asthma.Methods： Pub Med,CBM,CNKI,VIP and Wan Fang Data and other databases were retrieved for randomized controlled study literatures of Chinese medicine treatment for cold type asthma,dated from 1st January 1995 to 31 st October 2015 with search engine. Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies. Then,meta-analysis was performed with Rev Man 5. 3 software. Results： A total of 27 documents were included,with 2,475 cases. Meta-analysis of this showed that the observation group using Chinese medicine for cold type asthma treatment was more efficient than the control group using western medicine;Chinese medicine also improved the lung function indicators（FEV1,FEV1%,PEF%,FVC,PEFR）,and Chinese medicine treating the main symptoms（breath heaviky,chest tightness,sputum,wheezing） was better than western medicine,while both the treatment group and the control group had fair Results in improvement of PEF.Most of the included literatures did not study on the adverse effects of taking Chinese medicine. Therefore,there was no conclusion on the clinical safety of Chinese medicine treatment for cold type asthma. Conclusion： Based on current clinical evidences,Chinese medicine treatment for cold type asthma achieves better clinical results,but low quality exists due to trial methods. Thus,high-quality clinical studies with large sample,multi-center and the rational use of blinding are required in the future,in order to provide evaluation results with high reliability and accuracy.

关 键 词：中药 寒性哮喘 META分析 

分 类 号：R256.12[医药卫生—中医内科学]